INFLUENCE OF A STEADY LAMINAR SHEAR STRESS ON THE INTERNALIZATION OF LOW DENSITY LIPOPROTEINS BY CULTURED BOVINE AORTIC ENDOTHELIAL CELLS.

Bernd Steinbach; Eugene Sprague; Colin Schwartz; Robert Nerem

INFLUENCE OF A STEADY LAMINAR SHEAR STRESS ON THE INTERNALIZATION OF LOW DENSITY LIPOPROTEINS BY CULTURED BOVINE AORTIC ENDOTHELIAL CELLS.

Bernd Steinbach, Eugene Sprague, Colin Schwartz, Robert Nerem

Department of Medicine

Research output: Contribution to journal › Conference article › peer-review

Abstract

Low density lipoprotein (LDL) transport and receptor-mediated metabolism are believed to be key factors in atherogenesis. The purpose of this study was to establish a link between LDL-internalization and steady, laminar hemodynamic shear stress by subjecting cultured bovine aortic endothelial cells (BAEC) to a known shear stress in a parallel-plate, channel flow device. The present studies establish that the application of a laminar, steady wall shear stress to confluent BAEC cultures enhances the internalization of **1**2**5I-LDL. This effect appears to not be dependent upon prior shear-induced changes in cell shape and orientation, nor is it limited to the time period during which cell geometry is changing.

Original language	English (US)
Pages (from-to)	191-194
Number of pages	4
Journal	American Society of Mechanical Engineers, Applied Mechanics Division, AMD
Volume	84
State	Published - 1987

ASJC Scopus subject areas

Mechanical Engineering

Cite this

INFLUENCE OF A STEADY LAMINAR SHEAR STRESS ON THE INTERNALIZATION OF LOW DENSITY LIPOPROTEINS BY CULTURED BOVINE AORTIC ENDOTHELIAL CELLS. / Steinbach, Bernd; Sprague, Eugene; Schwartz, Colin et al.
In: American Society of Mechanical Engineers, Applied Mechanics Division, AMD, Vol. 84, 1987, p. 191-194.

Research output: Contribution to journal › Conference article › peer-review

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title = "INFLUENCE OF A STEADY LAMINAR SHEAR STRESS ON THE INTERNALIZATION OF LOW DENSITY LIPOPROTEINS BY CULTURED BOVINE AORTIC ENDOTHELIAL CELLS.",

abstract = "Low density lipoprotein (LDL) transport and receptor-mediated metabolism are believed to be key factors in atherogenesis. The purpose of this study was to establish a link between LDL-internalization and steady, laminar hemodynamic shear stress by subjecting cultured bovine aortic endothelial cells (BAEC) to a known shear stress in a parallel-plate, channel flow device. The present studies establish that the application of a laminar, steady wall shear stress to confluent BAEC cultures enhances the internalization of **1**2**5I-LDL. This effect appears to not be dependent upon prior shear-induced changes in cell shape and orientation, nor is it limited to the time period during which cell geometry is changing.",

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AU - Steinbach, Bernd

AU - Sprague, Eugene

AU - Schwartz, Colin

AU - Nerem, Robert

PY - 1987

Y1 - 1987

N2 - Low density lipoprotein (LDL) transport and receptor-mediated metabolism are believed to be key factors in atherogenesis. The purpose of this study was to establish a link between LDL-internalization and steady, laminar hemodynamic shear stress by subjecting cultured bovine aortic endothelial cells (BAEC) to a known shear stress in a parallel-plate, channel flow device. The present studies establish that the application of a laminar, steady wall shear stress to confluent BAEC cultures enhances the internalization of **1**2**5I-LDL. This effect appears to not be dependent upon prior shear-induced changes in cell shape and orientation, nor is it limited to the time period during which cell geometry is changing.

AB - Low density lipoprotein (LDL) transport and receptor-mediated metabolism are believed to be key factors in atherogenesis. The purpose of this study was to establish a link between LDL-internalization and steady, laminar hemodynamic shear stress by subjecting cultured bovine aortic endothelial cells (BAEC) to a known shear stress in a parallel-plate, channel flow device. The present studies establish that the application of a laminar, steady wall shear stress to confluent BAEC cultures enhances the internalization of **1**2**5I-LDL. This effect appears to not be dependent upon prior shear-induced changes in cell shape and orientation, nor is it limited to the time period during which cell geometry is changing.

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JO - American Society of Mechanical Engineers, Applied Mechanics Division, AMD

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INFLUENCE OF A STEADY LAMINAR SHEAR STRESS ON THE INTERNALIZATION OF LOW DENSITY LIPOPROTEINS BY CULTURED BOVINE AORTIC ENDOTHELIAL CELLS.

Abstract

ASJC Scopus subject areas

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