Influence of δ-sleep inducing peptide on melatonin synthesis in the rat pineal gland

Sol Oaknin; Maureen E. Troiani; Susan M. Webb; Russel J. Reiter

doi:10.1016/0304-3940(86)90450-7

Influence of δ-sleep inducing peptide on melatonin synthesis in the rat pineal gland

Sol Oaknin, Maureen E. Troiani, Susan M. Webb, Russel J. Reiter

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The influence of δ-sleep inducing peptide (DSIP) on rat pineal N-acetyltransferase (NAT) activity and melatonin levels was examined. Young adult rats received an injection of either saline or DSIP (either 15, 30 or 60 nmol/kg) at 20.00 h, immediately before lights out. DSIP at a dose of 15 nmol/kg significantly retarded the nighttime rise of pineal NAT activity and melatonin levels at 3 h into the dark phase. At the other two nocturnal time points (01.00 and 03.00 h) and the following morning (08.00 h) pineal NAT activity and melatonin levels were similar in all groups. The results confirmed a short-lived, dose-specific effect of DSIP on serotonin metabolism in the rat pineal gland.

Original language	English (US)
Pages (from-to)	127-131
Number of pages	5
Journal	Neuroscience Letters
Volume	70
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(86)90450-7
State	Published - Sep 25 1986

Keywords

Melatonin
N-Acetyltransferase
Pineal gland
Rat
δ-Sleep inducing peptide

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(86)90450-7

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@article{b78b0b2981a642cf9ad8ed7531433fa1,

title = "Influence of δ-sleep inducing peptide on melatonin synthesis in the rat pineal gland",

abstract = "The influence of δ-sleep inducing peptide (DSIP) on rat pineal N-acetyltransferase (NAT) activity and melatonin levels was examined. Young adult rats received an injection of either saline or DSIP (either 15, 30 or 60 nmol/kg) at 20.00 h, immediately before lights out. DSIP at a dose of 15 nmol/kg significantly retarded the nighttime rise of pineal NAT activity and melatonin levels at 3 h into the dark phase. At the other two nocturnal time points (01.00 and 03.00 h) and the following morning (08.00 h) pineal NAT activity and melatonin levels were similar in all groups. The results confirmed a short-lived, dose-specific effect of DSIP on serotonin metabolism in the rat pineal gland.",

keywords = "Melatonin, N-Acetyltransferase, Pineal gland, Rat, δ-Sleep inducing peptide",

author = "Sol Oaknin and Troiani, {Maureen E.} and Webb, {Susan M.} and Reiter, {Russel J.}",

note = "Funding Information: Researchs upportedb y NSF Grant 8410592G, rantC CA-8411106fr om the Spanish AmericanC ommitteea nd Caja Ahorros del Tenerife,L a Laguna University.",

year = "1986",

month = sep,

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doi = "10.1016/0304-3940(86)90450-7",

language = "English (US)",

volume = "70",

pages = "127--131",

journal = "Neuroscience Letters",

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T1 - Influence of δ-sleep inducing peptide on melatonin synthesis in the rat pineal gland

AU - Oaknin, Sol

AU - Troiani, Maureen E.

AU - Webb, Susan M.

AU - Reiter, Russel J.

N1 - Funding Information: Researchs upportedb y NSF Grant 8410592G, rantC CA-8411106fr om the Spanish AmericanC ommitteea nd Caja Ahorros del Tenerife,L a Laguna University.

PY - 1986/9/25

Y1 - 1986/9/25

N2 - The influence of δ-sleep inducing peptide (DSIP) on rat pineal N-acetyltransferase (NAT) activity and melatonin levels was examined. Young adult rats received an injection of either saline or DSIP (either 15, 30 or 60 nmol/kg) at 20.00 h, immediately before lights out. DSIP at a dose of 15 nmol/kg significantly retarded the nighttime rise of pineal NAT activity and melatonin levels at 3 h into the dark phase. At the other two nocturnal time points (01.00 and 03.00 h) and the following morning (08.00 h) pineal NAT activity and melatonin levels were similar in all groups. The results confirmed a short-lived, dose-specific effect of DSIP on serotonin metabolism in the rat pineal gland.

AB - The influence of δ-sleep inducing peptide (DSIP) on rat pineal N-acetyltransferase (NAT) activity and melatonin levels was examined. Young adult rats received an injection of either saline or DSIP (either 15, 30 or 60 nmol/kg) at 20.00 h, immediately before lights out. DSIP at a dose of 15 nmol/kg significantly retarded the nighttime rise of pineal NAT activity and melatonin levels at 3 h into the dark phase. At the other two nocturnal time points (01.00 and 03.00 h) and the following morning (08.00 h) pineal NAT activity and melatonin levels were similar in all groups. The results confirmed a short-lived, dose-specific effect of DSIP on serotonin metabolism in the rat pineal gland.

KW - Melatonin

KW - N-Acetyltransferase

KW - Pineal gland

KW - Rat

KW - δ-Sleep inducing peptide

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SN - 0304-3940

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EP - 131

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Influence of δ-sleep inducing peptide on melatonin synthesis in the rat pineal gland

Abstract

Keywords

ASJC Scopus subject areas

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