Abstract
Recent studies suggest dilated Virchow-Robin Spaces (dVRS) could be a manifestation of cerebral small-vessel disease, but little is known about their risk factors. As inflammation has been associated with other brain MRI findings, we investigated whether interleukin-6 and C-reactive protein were associated with the severity of dVRS in the eldery. dVRS were assessed in basal ganglia and white matter and rated on a severity scale. We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dVRS in the elderly.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 323-328 |
| Number of pages | 6 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2013 |
| Externally published | Yes |
Keywords
- Aged
- cerebral small vessel diseases
- dilated Virchow-Robin spaces
- inflammation
- magnetic resonance imaging
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Psychiatry and Mental health
- Clinical Psychology
- General Neuroscience
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