Inflammatory proteins and the severity of dilated Virchow-Robin spaces in the elderly

Claudia L. Satizabal, Yi Cheng Zhu, Carole Dufouil, Christophe Tzourio

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Recent studies suggest dilated Virchow-Robin Spaces (dVRS) could be a manifestation of cerebral small-vessel disease, but little is known about their risk factors. As inflammation has been associated with other brain MRI findings, we investigated whether interleukin-6 and C-reactive protein were associated with the severity of dVRS in the eldery. dVRS were assessed in basal ganglia and white matter and rated on a severity scale. We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dVRS in the elderly.

Original languageEnglish (US)
Pages (from-to)323-328
Number of pages6
JournalJournal of Alzheimer's Disease
Issue number2
StatePublished - 2013
Externally publishedYes


  • Aged
  • cerebral small vessel diseases
  • dilated Virchow-Robin spaces
  • inflammation
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Clinical Psychology
  • General Neuroscience


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