Inflammatory proteins and the severity of dilated Virchow-Robin spaces in the elderly

Claudia L. Satizabal; Yi Cheng Zhu; Carole Dufouil; Christophe Tzourio

doi:10.3233/JAD-2012-120874

Inflammatory proteins and the severity of dilated Virchow-Robin spaces in the elderly

Claudia L. Satizabal, Yi Cheng Zhu, Carole Dufouil, Christophe Tzourio

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Recent studies suggest dilated Virchow-Robin Spaces (dVRS) could be a manifestation of cerebral small-vessel disease, but little is known about their risk factors. As inflammation has been associated with other brain MRI findings, we investigated whether interleukin-6 and C-reactive protein were associated with the severity of dVRS in the eldery. dVRS were assessed in basal ganglia and white matter and rated on a severity scale. We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dVRS in the elderly.

Original language	English (US)
Pages (from-to)	323-328
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	33
Issue number	2
DOIs	https://doi.org/10.3233/JAD-2012-120874
State	Published - 2013
Externally published	Yes

Keywords

Aged
cerebral small vessel diseases
dilated Virchow-Robin spaces
inflammation
magnetic resonance imaging

ASJC Scopus subject areas

Geriatrics and Gerontology
Psychiatry and Mental health
Clinical Psychology
General Neuroscience

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abstract = "Recent studies suggest dilated Virchow-Robin Spaces (dVRS) could be a manifestation of cerebral small-vessel disease, but little is known about their risk factors. As inflammation has been associated with other brain MRI findings, we investigated whether interleukin-6 and C-reactive protein were associated with the severity of dVRS in the eldery. dVRS were assessed in basal ganglia and white matter and rated on a severity scale. We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dVRS in the elderly.",

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AU - Dufouil, Carole

AU - Tzourio, Christophe

PY - 2013

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AB - Recent studies suggest dilated Virchow-Robin Spaces (dVRS) could be a manifestation of cerebral small-vessel disease, but little is known about their risk factors. As inflammation has been associated with other brain MRI findings, we investigated whether interleukin-6 and C-reactive protein were associated with the severity of dVRS in the eldery. dVRS were assessed in basal ganglia and white matter and rated on a severity scale. We found that elevated interleukin-6 levels were associated with higher severity of dVRS in basal ganglia, suggesting that inflammation might be associated with the burden of dVRS in the elderly.

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Inflammatory proteins and the severity of dilated Virchow-Robin spaces in the elderly

Abstract

Keywords

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