Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: A Systematic Review

Rafael C. Magalhães, Letícia P. Pimenta, Izabela G. Barbosa, Janaina M. Moreira, João L.V.M. de Barros, Antônio L. Teixeira, Ana C. Simões e Silva

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Objective To provide a systematic review investigating the role of inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates. Data Source: Databases including PubMed, BIREME, and Scopus were systematically searched. Observational studies, as well as transversal, and cohort studies using human subjects published from 1990 to September 2017 were eligible for inclusion. Two authors independently identified eligible studies and analyzed their characteristics, quality, and accuracy in depth. Data synthesis: 11 eligible studies clearly investigated the association between peripheral inflammation and motor and/or cognitive development in preterm infants. However, the selected populations differed in relation to the events associated with prematurity and the risk factors to abnormal motor and/or cognitive development. These studies measured circulating levels of cytokines, chemokines, adhesion molecules, acute phase proteins, and growth factors. The most commonly analyzed proteins were IL-1β IL-6, TNF, CCL5/RANTES, CXCL8/IL-8, IGFBP-1, and VEGF. In seven of the eligible studies, plasma levels of IL-6 correlated with development delay. Two studies reported correlation between CXCL8/IL-8 plasma levels with cognitive and motor delay. In one study, higher levels of MCP-1/CCL2 were associated with better cognitive and motor outcome. Conclusion: There is preliminary evidence indicating that circulating inflammatory molecules are associated with motor and cognitive development in preterm neonates, even considering different populations.

Original languageEnglish (US)
Pages (from-to)29-37
Number of pages9
JournalInternational Journal of Developmental Neuroscience
Volume65
DOIs
StatePublished - Feb 2018
Externally publishedYes

Keywords

  • Cognitive development
  • Cytokines
  • Inflammation
  • Motor development
  • Neurotrophic factors
  • Preterm

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: A Systematic Review'. Together they form a unique fingerprint.

Cite this