TY - JOUR
T1 - Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates
T2 - A Systematic Review
AU - Magalhães, Rafael C.
AU - Pimenta, Letícia P.
AU - Barbosa, Izabela G.
AU - Moreira, Janaina M.
AU - de Barros, João L.V.M.
AU - Teixeira, Antônio L.
AU - Simões e Silva, Ana C.
N1 - Publisher Copyright:
© 2017 ISDN
PY - 2018/2
Y1 - 2018/2
N2 - Objective To provide a systematic review investigating the role of inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates. Data Source: Databases including PubMed, BIREME, and Scopus were systematically searched. Observational studies, as well as transversal, and cohort studies using human subjects published from 1990 to September 2017 were eligible for inclusion. Two authors independently identified eligible studies and analyzed their characteristics, quality, and accuracy in depth. Data synthesis: 11 eligible studies clearly investigated the association between peripheral inflammation and motor and/or cognitive development in preterm infants. However, the selected populations differed in relation to the events associated with prematurity and the risk factors to abnormal motor and/or cognitive development. These studies measured circulating levels of cytokines, chemokines, adhesion molecules, acute phase proteins, and growth factors. The most commonly analyzed proteins were IL-1β IL-6, TNF, CCL5/RANTES, CXCL8/IL-8, IGFBP-1, and VEGF. In seven of the eligible studies, plasma levels of IL-6 correlated with development delay. Two studies reported correlation between CXCL8/IL-8 plasma levels with cognitive and motor delay. In one study, higher levels of MCP-1/CCL2 were associated with better cognitive and motor outcome. Conclusion: There is preliminary evidence indicating that circulating inflammatory molecules are associated with motor and cognitive development in preterm neonates, even considering different populations.
AB - Objective To provide a systematic review investigating the role of inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates. Data Source: Databases including PubMed, BIREME, and Scopus were systematically searched. Observational studies, as well as transversal, and cohort studies using human subjects published from 1990 to September 2017 were eligible for inclusion. Two authors independently identified eligible studies and analyzed their characteristics, quality, and accuracy in depth. Data synthesis: 11 eligible studies clearly investigated the association between peripheral inflammation and motor and/or cognitive development in preterm infants. However, the selected populations differed in relation to the events associated with prematurity and the risk factors to abnormal motor and/or cognitive development. These studies measured circulating levels of cytokines, chemokines, adhesion molecules, acute phase proteins, and growth factors. The most commonly analyzed proteins were IL-1β IL-6, TNF, CCL5/RANTES, CXCL8/IL-8, IGFBP-1, and VEGF. In seven of the eligible studies, plasma levels of IL-6 correlated with development delay. Two studies reported correlation between CXCL8/IL-8 plasma levels with cognitive and motor delay. In one study, higher levels of MCP-1/CCL2 were associated with better cognitive and motor outcome. Conclusion: There is preliminary evidence indicating that circulating inflammatory molecules are associated with motor and cognitive development in preterm neonates, even considering different populations.
KW - Cognitive development
KW - Cytokines
KW - Inflammation
KW - Motor development
KW - Neurotrophic factors
KW - Preterm
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U2 - 10.1016/j.ijdevneu.2017.10.006
DO - 10.1016/j.ijdevneu.2017.10.006
M3 - Review article
C2 - 29051031
AN - SCOPUS:85031490011
SN - 0736-5748
VL - 65
SP - 29
EP - 37
JO - International Journal of Developmental Neuroscience
JF - International Journal of Developmental Neuroscience
ER -