Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice

Norinne Lacerda-Queiroz; David Henrique Rodrigues; Márcia Carvalho Vilela; Aline Silva de Miranda; Débora Cristina Guerra Amaral; Elizabeth Ribeiro da Silva Camargos; Leonardo José de Moura Carvalho; Charles L. Howe; Mauro Martins Teixeira; Antônio Lúcio Teixeira

doi:10.1016/j.exppara.2010.02.002

Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice

Norinne Lacerda-Queiroz, David Henrique Rodrigues, Márcia Carvalho Vilela, Aline Silva de Miranda, Débora Cristina Guerra Amaral, Elizabeth Ribeiro da Silva Camargos, Leonardo José de Moura Carvalho, Charles L. Howe, Mauro Martins Teixeira, Antônio Lúcio Teixeira

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Experimental cerebral malaria is a neuroinflammatory condition that results from the host immune response to the parasite. Using intravital microscopy, we investigated leukocyte recruitment in the brain microcirculation and the temporal relationship of this process to the behavioral changes observed in Plasmodium berghei (strain ANKA)-infected C57Bl/6 mice. We found that leukocyte recruitment was increased from day 5 post-infection (p.i.) onwards. Histopathological changes and increased levels of inflammatory cytokines in the brain were also observed. Behavioral performance evaluated by the SHIRPA protocol showed functional impairment from day 6 p.i. onwards. Thus, early leukocyte migration into the brain and associated inflammatory changes may be involved in neurological impairment in parasite-infected C57Bl/6 mice.

Original language	English (US)
Pages (from-to)	271-278
Number of pages	8
Journal	Experimental Parasitology
Volume	125
Issue number	3
DOIs	https://doi.org/10.1016/j.exppara.2010.02.002
State	Published - Jul 2010
Externally published	Yes

Keywords

Behavior
Cerebral malaria
Cytokines
Intravital microscopy
Leukocyte recruitment

ASJC Scopus subject areas

Parasitology
Immunology
Infectious Diseases

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10.1016/j.exppara.2010.02.002

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Lacerda-Queiroz, N., Rodrigues, D. H., Vilela, M. C., Miranda, A. S. D., Amaral, D. C. G., Camargos, E. R. D. S., Carvalho, L. J. D. M., Howe, C. L., Teixeira, M. M., & Teixeira, A. L. (2010). Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice. Experimental Parasitology, 125(3), 271-278. https://doi.org/10.1016/j.exppara.2010.02.002

Lacerda-Queiroz, N, Rodrigues, DH, Vilela, MC, Miranda, ASD, Amaral, DCG, Camargos, ERDS, Carvalho, LJDM, Howe, CL, Teixeira, MM & Teixeira, AL 2010, 'Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice', Experimental Parasitology, vol. 125, no. 3, pp. 271-278. https://doi.org/10.1016/j.exppara.2010.02.002

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title = "Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice",

abstract = "Experimental cerebral malaria is a neuroinflammatory condition that results from the host immune response to the parasite. Using intravital microscopy, we investigated leukocyte recruitment in the brain microcirculation and the temporal relationship of this process to the behavioral changes observed in Plasmodium berghei (strain ANKA)-infected C57Bl/6 mice. We found that leukocyte recruitment was increased from day 5 post-infection (p.i.) onwards. Histopathological changes and increased levels of inflammatory cytokines in the brain were also observed. Behavioral performance evaluated by the SHIRPA protocol showed functional impairment from day 6 p.i. onwards. Thus, early leukocyte migration into the brain and associated inflammatory changes may be involved in neurological impairment in parasite-infected C57Bl/6 mice.",

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AU - Miranda, Aline Silva de

AU - Amaral, Débora Cristina Guerra

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AU - Carvalho, Leonardo José de Moura

AU - Howe, Charles L.

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Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice

Abstract

Keywords

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