Inflammatory biomarkers responses after acute whole body vibration in fibromyalgia

V. G.C. Ribeiro, V. A. Mendonça, A. L.C. Souza, S. F. Fonseca, A. C.R. Camargos, V. K.S. Lage, C. D.C. Neves, J. M. Santos, L. A.C. Teixeira, E. L.M. Vieira, A. L. Teixeira Junior, B. Mezêncio, J. S.C. Fernandes, H. R. Leite, J. R. Poortmans, A. C.R. Lacerda

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The aims of this study were 1) to characterize the intensity of the vibration stimulation in women diagnosed with fibromyalgia (FM) compared to a control group of healthy women (HW) matched by age and anthropometric parameters, and 2) to investigate the effect of a single session of whole body vibration (WBV) on inflammatory responses. Levels of adipokines, soluble tumor necrosis factor receptors (sTNFr1, sTNFr2), and brain-derived neurotrophic factor (BDNF) were determined by enzyme-linked immunosorbent assay. Oxygen consumption (VO2) was estimated by a portable gas analysis system, heart rate (HR) was measured using a HR monitor, and perceived exertion (RPE) was evaluated using the Borg scale of perceived exertion. Acutely mild WBV increased VO2 and HR similarly in both groups. There was an interaction (disease vs vibration) in RPE (P=0.0078), showing a higher RPE in FM compared to HW at rest, which further increased in FM after acute WBV, whereas it remained unchanged in HW. In addition, there was an interaction (disease vs vibration) in plasma levels of adiponectin (P=0.0001), sTNFR1 (P=0.000001), sTNFR2 (P=0.0052), leptin (P=0.0007), resistin (P=0.0166), and BDNF (P=0.0179). In conclusion, a single acute session of mild and short WBV can improve the inflammatory status in patients with FM, reaching values close to those of matched HW at their basal status. The neuroendocrine mechanism seems to be an exercise-induced modulation towards greater adaptation to stress response in these patients.

Original languageEnglish (US)
Article numbere6775
JournalBrazilian Journal of Medical and Biological Research
Volume51
Issue number4
DOIs
StatePublished - 2018
Externally publishedYes

Keywords

  • Acute exercise
  • Biomarkers
  • Clinical trial
  • Fibromyalgia
  • Inflammation

ASJC Scopus subject areas

  • Biophysics
  • General Neuroscience
  • Biochemistry
  • Physiology
  • Immunology
  • General Pharmacology, Toxicology and Pharmaceutics
  • Cell Biology

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