Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study

Oluchi Ekenze, Adlin Pinheiro, Serkalem Demissie, Andreas Charidimou, Alexa S Beiser, Ramachandran S Vasan, Emelia J Benjamin, Charles DeCarli, Sudha Seshadri, Jose R Romero

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We studied the association between inflammatory biomarkers and magnetic resonance imaging (MRI) visible perivascular spaces (PVS) in Framingham Heart Study participants free of stroke and dementia. PVS in the basal ganglia (BG) and centrum semiovale (CSO) were rated with validated methods and categorized based on counts. A mixed score of high PVS burden in neither, one or both regions was also evaluated. We related biomarkers representing various inflammatory mechanisms to PVS burden using multivariable ordinal logistic regression analysis accounting for vascular risk factors and other MRI markers of cerebral small vessel disease. Among 3604 participants (mean age 58±13 years, 47% males), significant associations were observed for intercellular adhesion molecule1, fibrinogen, osteoprotegerin, and P-selectin in relation to BG PVS, P-selectin for CSO PVS, and tumor necrosis factor receptor 2, osteoprotegerin and cluster of differentiation 40 ligand for mixed topography PVS. Therefore, inflammation may have a role in the pathogenesis of cerebral small vessel disease and perivascular drainage dysfunction represented by PVS, with different and shared inflammatory biomarkers depending on PVS topography.

Original languageEnglish (US)
Pages (from-to)12-22
Number of pages11
JournalNeurobiology of Aging
StatePublished - Jul 2023


  • Male
  • Humans
  • Aged
  • Female
  • Osteoprotegerin
  • P-Selectin
  • Biomarkers
  • Longitudinal Studies
  • Magnetic Resonance Imaging/methods
  • Cerebral Small Vessel Diseases/pathology


Dive into the research topics of 'Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study'. Together they form a unique fingerprint.

Cite this