Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study

Oluchi Ekenze; Adlin Pinheiro; Serkalem Demissie; Andreas Charidimou; Alexa S Beiser; Ramachandran S Vasan; Emelia J Benjamin; Charles DeCarli; Sudha Seshadri; Jose R Romero

doi:10.1016/j.neurobiolaging.2023.03.001

Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study

Oluchi Ekenze, Adlin Pinheiro, Serkalem Demissie, Andreas Charidimou, Alexa S Beiser, Ramachandran S Vasan, Emelia J Benjamin, Charles DeCarli, Sudha Seshadri, Jose R Romero

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We studied the association between inflammatory biomarkers and magnetic resonance imaging (MRI) visible perivascular spaces (PVS) in Framingham Heart Study participants free of stroke and dementia. PVS in the basal ganglia (BG) and centrum semiovale (CSO) were rated with validated methods and categorized based on counts. A mixed score of high PVS burden in neither, one or both regions was also evaluated. We related biomarkers representing various inflammatory mechanisms to PVS burden using multivariable ordinal logistic regression analysis accounting for vascular risk factors and other MRI markers of cerebral small vessel disease. Among 3604 participants (mean age 58±13 years, 47% males), significant associations were observed for intercellular adhesion molecule1, fibrinogen, osteoprotegerin, and P-selectin in relation to BG PVS, P-selectin for CSO PVS, and tumor necrosis factor receptor 2, osteoprotegerin and cluster of differentiation 40 ligand for mixed topography PVS. Therefore, inflammation may have a role in the pathogenesis of cerebral small vessel disease and perivascular drainage dysfunction represented by PVS, with different and shared inflammatory biomarkers depending on PVS topography.

Original language	English (US)
Pages (from-to)	12-22
Number of pages	11
Journal	Neurobiology of Aging
Volume	127
DOIs	https://doi.org/10.1016/j.neurobiolaging.2023.03.001
State	Published - Jul 2023

Keywords

Male
Humans
Aged
Female
Osteoprotegerin
P-Selectin
Biomarkers
Longitudinal Studies
Magnetic Resonance Imaging/methods
Cerebral Small Vessel Diseases/pathology

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10.1016/j.neurobiolaging.2023.03.001

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@article{23727da0feb944169f8f232037ae70c1,

title = "Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study",

abstract = "We studied the association between inflammatory biomarkers and magnetic resonance imaging (MRI) visible perivascular spaces (PVS) in Framingham Heart Study participants free of stroke and dementia. PVS in the basal ganglia (BG) and centrum semiovale (CSO) were rated with validated methods and categorized based on counts. A mixed score of high PVS burden in neither, one or both regions was also evaluated. We related biomarkers representing various inflammatory mechanisms to PVS burden using multivariable ordinal logistic regression analysis accounting for vascular risk factors and other MRI markers of cerebral small vessel disease. Among 3604 participants (mean age 58±13 years, 47% males), significant associations were observed for intercellular adhesion molecule1, fibrinogen, osteoprotegerin, and P-selectin in relation to BG PVS, P-selectin for CSO PVS, and tumor necrosis factor receptor 2, osteoprotegerin and cluster of differentiation 40 ligand for mixed topography PVS. Therefore, inflammation may have a role in the pathogenesis of cerebral small vessel disease and perivascular drainage dysfunction represented by PVS, with different and shared inflammatory biomarkers depending on PVS topography.",

keywords = "Male, Humans, Aged, Female, Osteoprotegerin, P-Selectin, Biomarkers, Longitudinal Studies, Magnetic Resonance Imaging/methods, Cerebral Small Vessel Diseases/pathology",

author = "Oluchi Ekenze and Adlin Pinheiro and Serkalem Demissie and Andreas Charidimou and Beiser, {Alexa S} and Vasan, {Ramachandran S} and Benjamin, {Emelia J} and Charles DeCarli and Sudha Seshadri and Romero, {Jose R}",

year = "2023",

month = jul,

doi = "10.1016/j.neurobiolaging.2023.03.001",

language = "English (US)",

volume = "127",

pages = "12--22",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

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T1 - Inflammatory biomarkers and MRI visible perivascular spaces

T2 - The Framingham Heart Study

AU - Ekenze, Oluchi

AU - Pinheiro, Adlin

AU - Demissie, Serkalem

AU - Charidimou, Andreas

AU - Beiser, Alexa S

AU - Vasan, Ramachandran S

AU - Benjamin, Emelia J

AU - DeCarli, Charles

AU - Seshadri, Sudha

AU - Romero, Jose R

PY - 2023/7

Y1 - 2023/7

N2 - We studied the association between inflammatory biomarkers and magnetic resonance imaging (MRI) visible perivascular spaces (PVS) in Framingham Heart Study participants free of stroke and dementia. PVS in the basal ganglia (BG) and centrum semiovale (CSO) were rated with validated methods and categorized based on counts. A mixed score of high PVS burden in neither, one or both regions was also evaluated. We related biomarkers representing various inflammatory mechanisms to PVS burden using multivariable ordinal logistic regression analysis accounting for vascular risk factors and other MRI markers of cerebral small vessel disease. Among 3604 participants (mean age 58±13 years, 47% males), significant associations were observed for intercellular adhesion molecule1, fibrinogen, osteoprotegerin, and P-selectin in relation to BG PVS, P-selectin for CSO PVS, and tumor necrosis factor receptor 2, osteoprotegerin and cluster of differentiation 40 ligand for mixed topography PVS. Therefore, inflammation may have a role in the pathogenesis of cerebral small vessel disease and perivascular drainage dysfunction represented by PVS, with different and shared inflammatory biomarkers depending on PVS topography.

AB - We studied the association between inflammatory biomarkers and magnetic resonance imaging (MRI) visible perivascular spaces (PVS) in Framingham Heart Study participants free of stroke and dementia. PVS in the basal ganglia (BG) and centrum semiovale (CSO) were rated with validated methods and categorized based on counts. A mixed score of high PVS burden in neither, one or both regions was also evaluated. We related biomarkers representing various inflammatory mechanisms to PVS burden using multivariable ordinal logistic regression analysis accounting for vascular risk factors and other MRI markers of cerebral small vessel disease. Among 3604 participants (mean age 58±13 years, 47% males), significant associations were observed for intercellular adhesion molecule1, fibrinogen, osteoprotegerin, and P-selectin in relation to BG PVS, P-selectin for CSO PVS, and tumor necrosis factor receptor 2, osteoprotegerin and cluster of differentiation 40 ligand for mixed topography PVS. Therefore, inflammation may have a role in the pathogenesis of cerebral small vessel disease and perivascular drainage dysfunction represented by PVS, with different and shared inflammatory biomarkers depending on PVS topography.

KW - Male

KW - Humans

KW - Aged

KW - Female

KW - Osteoprotegerin

KW - P-Selectin

KW - Biomarkers

KW - Longitudinal Studies

KW - Magnetic Resonance Imaging/methods

KW - Cerebral Small Vessel Diseases/pathology

U2 - 10.1016/j.neurobiolaging.2023.03.001

DO - 10.1016/j.neurobiolaging.2023.03.001

M3 - Article

C2 - 37018882

SN - 0197-4580

VL - 127

SP - 12

EP - 22

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study

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Keywords

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