Inflammation in Huntington's disease: A few new twists on an old tale

Priscila Aparecida Costa Valadão, Kívia Barretos S. Santos, Talita Hélen Ferreira e Vieira, Thiago Macedo e Cordeiro, Antonio Lucio Teixeira, Cristina Guatimosim, Aline Silva de Miranda

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations

Abstract

Huntington's disease (HD) is a neurodegenerative disease characterized by prominent loss of neurons in the striatum and cortex. Traditionally research in HD has focused on brain changes as they cause progressive motor dysfunction, cognitive decline and psychiatric disorders. The discovery that huntingtin protein (HTT) and its mutated form (mHTT) are expressed not only in the brain but also in different organs and tissues paved the way for the hypothesis that HD might affect regions beyond the central nervous system (CNS). Besides pathological deposition of mHTT, other mechanisms, including inflammation, seem to underlie HD pathogenesis and progression. Altered inflammation can be evidenced even before the onset of classical symptoms of HD. Herein, we will discuss current pre-clinical and clinical evidence on immune/inflammatory changes in peripheral organs during HD development and progression. The understanding of the impact of inflammation on peripheral organs may open new venues for the development of novel therapeutic targets in HD.

Original languageEnglish (US)
Article number577380
JournalJournal of Neuroimmunology
Volume348
DOIs
StatePublished - Nov 15 2020
Externally publishedYes

Keywords

  • Huntingtin protein
  • Huntington's disease
  • Inflammation
  • Peripheral organs

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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