TY - JOUR
T1 - Inflammation, epigenetics, and metabolism converge to cell senescence and ageing
T2 - the regulation and intervention
AU - Zhu, Xudong
AU - Chen, Zhiyang
AU - Shen, Weiyan
AU - Huang, Gang
AU - Sedivy, John M.
AU - Wang, Hu
AU - Ju, Zhenyu
N1 - Funding Information:
This work was supported by Grants 2016YFA0100602, 2017YFA0103302, and 2018YFA0109300 from the National Key Research and Development Program of China; Grants 81525010, 81770155, 91749117, 91749203, 81901403, 82030039, 82022026, and 82071572 from the National Natural Science Foundation of China; Grant 2C32003 from Opening Project of Key Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province; Grant 2019B151502008 from the Science Foundation for Distinguished Young Scholars of Guangdong Province; Grant 2018GZR110103002 from Innovative Team Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory; and Grant 2017ZT07S347 from the Program for Guangdong Introducing Innovative and Enterpreneurial Teams. Figures 3–5 are created with BioRender.com.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Remarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that the decline of physical function often initiates by cell senescence and organ ageing. Epigenetic dynamics and immunometabolic reprogramming link to the alterations of cellular response to intrinsic and extrinsic stimuli, representing current hotspots as they not only (re-)shape the individual cell identity, but also involve in cell fate decision. This review focuses on the present findings and emerging concepts in epigenetic, inflammatory, and metabolic regulations and the consequences of the ageing process. Potential therapeutic interventions targeting cell senescence and regulatory mechanisms, using state-of-the-art techniques are also discussed.
AB - Remarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that the decline of physical function often initiates by cell senescence and organ ageing. Epigenetic dynamics and immunometabolic reprogramming link to the alterations of cellular response to intrinsic and extrinsic stimuli, representing current hotspots as they not only (re-)shape the individual cell identity, but also involve in cell fate decision. This review focuses on the present findings and emerging concepts in epigenetic, inflammatory, and metabolic regulations and the consequences of the ageing process. Potential therapeutic interventions targeting cell senescence and regulatory mechanisms, using state-of-the-art techniques are also discussed.
UR - http://www.scopus.com/inward/record.url?scp=85108940645&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85108940645&partnerID=8YFLogxK
U2 - 10.1038/s41392-021-00646-9
DO - 10.1038/s41392-021-00646-9
M3 - Review article
C2 - 34176928
AN - SCOPUS:85108940645
SN - 2095-9907
VL - 6
JO - Signal Transduction and Targeted Therapy
JF - Signal Transduction and Targeted Therapy
IS - 1
M1 - 245
ER -