Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

Xudong Zhu, Zhiyang Chen, Weiyan Shen, Gang Huang, John M. Sedivy, Hu Wang, Zhenyu Ju

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Remarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that the decline of physical function often initiates by cell senescence and organ ageing. Epigenetic dynamics and immunometabolic reprogramming link to the alterations of cellular response to intrinsic and extrinsic stimuli, representing current hotspots as they not only (re-)shape the individual cell identity, but also involve in cell fate decision. This review focuses on the present findings and emerging concepts in epigenetic, inflammatory, and metabolic regulations and the consequences of the ageing process. Potential therapeutic interventions targeting cell senescence and regulatory mechanisms, using state-of-the-art techniques are also discussed.

Original languageEnglish (US)
Article number245
JournalSignal Transduction and Targeted Therapy
Volume6
Issue number1
DOIs
StatePublished - Dec 2021
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Fingerprint

Dive into the research topics of 'Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention'. Together they form a unique fingerprint.

Cite this