Infertility and Subclinical Antecedents of Heart Failure With Preserved Ejection Fraction in the Framingham Heart Study

JOYCE C. ZHOU, YUNONG ZHAO, NATALIE BELLO, EMELIA J. BENJAMIN, VASAN S. RAMACHANDRAN, DANIEL LEVY, SUSAN CHENG, JOANNE M. MURABITO, JENNIFER E. HO, EMILY S. LAU

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Infertility has been shown to be associated with a greater risk of incident heart failure with preserved ejection fraction. We studied the association of infertility with subclinical markers of heart failure with preserved ejection fraction, including echocardiographic signs of cardiac remodeling and cardiac biomarkers. Methods and Results: A history of infertility was ascertained in 2002 women enrolled in the Framingham Heart Study. We examined the association of infertility with echocardiographic measures and cardiac biomarkers with multivariable-adjusted linear regression models. Among 2002 women (mean age 40.84 ± 9.71 years), 285 (14%) reported a history of infertility. Infertility was associated with a greater E/e′ ratio (β = 0.120, standard error 0.057, P = .04), even after adjustment for common confounders. Infertility was not associated with other echocardiographic measures or cardiac biomarkers. Conclusions: Infertility was associated with a greater E/e′ ratio, a marker of diastolic dysfunction that may signal earlier subclinical cardiac remodeling in women with infertility.

Original languageEnglish (US)
Pages (from-to)513-515
Number of pages3
JournalJournal of Cardiac Failure
Volume30
Issue number3
DOIs
StatePublished - Mar 2024
Externally publishedYes

Keywords

  • Infertility
  • biomarkers
  • echocardiography
  • heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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