TY - JOUR
T1 - Infections and use of antibiotics in patients admitted for severe acute pancreatitis
T2 - Data from the epic II study
AU - De Waele, Jan J.
AU - Rello, Jordi
AU - Anzueto, Antonio
AU - Moreno, Rui
AU - Lipman, Jeffrey
AU - Sakr, Yasser
AU - Pickkers, Peter
AU - Leone, Marc
AU - Ferguson, Andrew
AU - Oud, Lavi
AU - Vincent, Jean Louis
PY - 2014/8/1
Y1 - 2014/8/1
N2 - Infectious complications are frequent in severe acute pancreatitis (SAP) but multinational epidemiologic data are lacking. The aim of the study was to analyze the characteristics of the infectious complications and antimicrobial use in this setting. Methods: One-day point prevalence study of infection in critically ill patients (Extended Prevalence of Infection in the ICU-II study), performed in 1,265 ICUs in 75 countries. Results: Of the 13,796 patients in the study, 159 were admitted with SAP. One-hundred sixteen (73%) had infections: 31% intra-abdominal, 16% extra-abdominal, and 26% both. Gram-negative bacteria were more prevalent than gram-positive organisms, anaerobes, or fungi. Therapeutically, penicillins and other beta-lactams were used most frequently. Prophylactic antibiotics were administered to 24% of the patients with SAP. Conclusions: Infections are frequent in patients admitted with SAP; most are intra-abdominal infections. Microbiology is diverse with gram-negative micro-organisms most frequently isolated. Most patients admitted to the ICU for SAP receive antibiotics at some point.
AB - Infectious complications are frequent in severe acute pancreatitis (SAP) but multinational epidemiologic data are lacking. The aim of the study was to analyze the characteristics of the infectious complications and antimicrobial use in this setting. Methods: One-day point prevalence study of infection in critically ill patients (Extended Prevalence of Infection in the ICU-II study), performed in 1,265 ICUs in 75 countries. Results: Of the 13,796 patients in the study, 159 were admitted with SAP. One-hundred sixteen (73%) had infections: 31% intra-abdominal, 16% extra-abdominal, and 26% both. Gram-negative bacteria were more prevalent than gram-positive organisms, anaerobes, or fungi. Therapeutically, penicillins and other beta-lactams were used most frequently. Prophylactic antibiotics were administered to 24% of the patients with SAP. Conclusions: Infections are frequent in patients admitted with SAP; most are intra-abdominal infections. Microbiology is diverse with gram-negative micro-organisms most frequently isolated. Most patients admitted to the ICU for SAP receive antibiotics at some point.
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U2 - 10.1089/sur.2012.228
DO - 10.1089/sur.2012.228
M3 - Article
C2 - 24819027
AN - SCOPUS:84906250649
SN - 1096-2964
VL - 15
SP - 394
EP - 398
JO - Surgical infections
JF - Surgical infections
IS - 4
ER -