Infection of rabbits with human immunodeficiency virus 1. A small animal model for acquired immunodeficiency syndrome

H. Kulaga, T. Folks, R. Rutledge, M. E. Truckenmiller, E. Gugel, T. J. Kindt

    Research output: Contribution to journalArticle

    46 Scopus citations

    Abstract

    Injection of rabbits with a human T cell line infected with HIV-1 caused seroconversion within 6 wk, and HIV-1 could be isolated from PBL cultures of infected rabbits. Identity of the isolated virus with HIV-1 was shown by analysis of products amplified by the polymerase chain reaction. HIV-1 infection was seen in rabbits injected with HIV-1-infected cells alone as well as in those that were first infected with HTLV-1 and subsequently with HIV-1. There were no consistent signs of disease in the rabbits infected with HIV-1 alone but HTLV-1/HIV-1-infected rabbits showed signs of illness including diarrhea and weight loss, transient neurologic impairment and, in one animal, a rapidly progressing mammary adenocarcinoma. Examination of organs taken at necropsy from both HIV-1- and HTLV-1/HIV-1-infected animals showed splenic hyperplasia and lymphocyte infiltration of the lungs, as well as moderate damage to liver and kidney in some cases.

    Original languageEnglish (US)
    Pages (from-to)321-326
    Number of pages6
    JournalJournal of Experimental Medicine
    Volume169
    Issue number1
    DOIs
    StatePublished - 1989

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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