Infection of myocytes with chlamydiae

Guqi Wang, Frank Burczynski, Brian Hasinoff, Guangming Zhon

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Chlamydial infection has been associated with myocarditis in animals and humans. However, the mechanism resulting in myocarditis following infection is not known. Here, evidence is presented that both Chlamydia trachomatis and Chlamydia pneumoniae can infect and replicate in myocytes isolated from neonate rats. The infected myocytes contained chlamydial inclusions, indicative of chlamydial growth, and infectious particles were recovered from the infected myocytes. It was also found that chlamydial infection at a late stage induced significant damage to the infected myocytes, as evidenced by an increased lactate dehydrogenase release, reactive oxygen species production and a reduced ATP level. However, no nuclear apoptosis was detected in the infected myocytes. Collectively, these observations have demonstrated that Chlamydia spp. are able to both infect and damage myocytes, suggesting a potential role of chlamydial infection in myocarditis.

Original languageEnglish (US)
Pages (from-to)3955-3959
Number of pages5
Issue number12
StatePublished - Dec 1 2002


  • Apoptosis
  • Chlamydial infection
  • Myocarditis
  • Myocytes

ASJC Scopus subject areas

  • Microbiology


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