Infection of Human Gastrointestinal Cells by HIV-1

Mary Pat Moyer; Rachel I. Huot; Adolph Ramirez; Steven Joe; Monte S. Meltzer; Howard E. Gendelman

doi:10.1089/aid.1990.6.1409

Infection of Human Gastrointestinal Cells by HIV-1

Mary Pat Moyer
, Rachel I. Huot
, Adolph Ramirez
, Steven Joe
, Monte S. Meltzer
, Howard E. Gendelman

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Human immunodeficiency virus (HIV-1) infected and replicated in primary cultures of normal human ileal and colonic epithelial cells. Monocyte-tropic strains (ADA, 24, and 36) were better able to replicate in the gastrointestinal (GI) cells than the T-cell-tropic HIV strain HTLV-IIIB. In some cultures, virus replication persisted through several months. Intestinal epithelium may be an initial target and reservoir for HIV and a vector for virus dissemination and transmission.

Original language	English (US)
Pages (from-to)	1409-1415
Number of pages	7
Journal	AIDS Research and Human Retroviruses
Volume	6
Issue number	12
DOIs	https://doi.org/10.1089/aid.1990.6.1409
State	Published - Dec 1990

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

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10.1089/aid.1990.6.1409

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abstract = "Human immunodeficiency virus (HIV-1) infected and replicated in primary cultures of normal human ileal and colonic epithelial cells. Monocyte-tropic strains (ADA, 24, and 36) were better able to replicate in the gastrointestinal (GI) cells than the T-cell-tropic HIV strain HTLV-IIIB. In some cultures, virus replication persisted through several months. Intestinal epithelium may be an initial target and reservoir for HIV and a vector for virus dissemination and transmission.",

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AU - Moyer, Mary Pat

AU - Huot, Rachel I.

AU - Ramirez, Adolph

AU - Joe, Steven

AU - Meltzer, Monte S.

AU - Gendelman, Howard E.

PY - 1990/12

Y1 - 1990/12

N2 - Human immunodeficiency virus (HIV-1) infected and replicated in primary cultures of normal human ileal and colonic epithelial cells. Monocyte-tropic strains (ADA, 24, and 36) were better able to replicate in the gastrointestinal (GI) cells than the T-cell-tropic HIV strain HTLV-IIIB. In some cultures, virus replication persisted through several months. Intestinal epithelium may be an initial target and reservoir for HIV and a vector for virus dissemination and transmission.

AB - Human immunodeficiency virus (HIV-1) infected and replicated in primary cultures of normal human ileal and colonic epithelial cells. Monocyte-tropic strains (ADA, 24, and 36) were better able to replicate in the gastrointestinal (GI) cells than the T-cell-tropic HIV strain HTLV-IIIB. In some cultures, virus replication persisted through several months. Intestinal epithelium may be an initial target and reservoir for HIV and a vector for virus dissemination and transmission.

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U2 - 10.1089/aid.1990.6.1409

DO - 10.1089/aid.1990.6.1409

M3 - Article

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AN - SCOPUS:0025645606

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JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

IS - 12

ER -

Infection of Human Gastrointestinal Cells by HIV-1

Abstract

ASJC Scopus subject areas

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