Infection of a Laboratory Worker with Simian Immunodeficiency Virus

Rima F. Khabbaz, Walid Heneine, J. Richard George, Bharat Parekh, Thomas Rowe, Toni Woods, William M. Switzer, Harold M. Mcclure, Michael Murphey-Corb, Thomas M. Folks

    Research output: Contribution to journalArticle

    104 Scopus citations

    Abstract

    Simian immunodeficiency viruses (SIVs) are primate lentiviruses that are morphologically similar and biologically related to human immunodeficiency viruses (HIVs)14. SIVs naturally infect some nonhuman primate species, such as African green monkeys and sooty mangabey monkeys, without causing immunodeficiency. In contrast, experimental SIV infection of other susceptible primate species, such as macaques, can cause chronic wasting syndromes and a disease similar to the human acquired immunodeficiency syndrome (AIDS)510. Because of the similarities between the human and nonhuman lentiviruses, SIV and its susceptible primate host have become the principal model for studying the pathogenesis of AIDS and developing…

    Original languageEnglish (US)
    Pages (from-to)172-177
    Number of pages6
    JournalNew England Journal of Medicine
    Volume330
    Issue number3
    DOIs
    StatePublished - Jan 20 1994

    ASJC Scopus subject areas

    • Medicine(all)

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  • Cite this

    Khabbaz, R. F., Heneine, W., George, J. R., Parekh, B., Rowe, T., Woods, T., Switzer, W. M., Mcclure, H. M., Murphey-Corb, M., & Folks, T. M. (1994). Infection of a Laboratory Worker with Simian Immunodeficiency Virus. New England Journal of Medicine, 330(3), 172-177. https://doi.org/10.1056/NEJM199401203300304