Infection of a Laboratory Worker with Simian Immunodeficiency Virus

Rima F. Khabbaz; Walid Heneine; J. Richard George; Bharat Parekh; Thomas Rowe; Toni Woods; William M. Switzer; Harold M. Mcclure; Michael Murphey-Corb; Thomas M. Folks

doi:10.1056/NEJM199401203300304

Infection of a Laboratory Worker with Simian Immunodeficiency Virus

Rima F. Khabbaz, Walid Heneine, J. Richard George, Bharat Parekh, Thomas Rowe, Toni Woods, William M. Switzer, Harold M. Mcclure, Michael Murphey-Corb, Thomas M. Folks

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Simian immunodeficiency viruses (SIVs) are primate lentiviruses that are morphologically similar and biologically related to human immunodeficiency viruses (HIVs)¹–⁴. SIVs naturally infect some nonhuman primate species, such as African green monkeys and sooty mangabey monkeys, without causing immunodeficiency. In contrast, experimental SIV infection of other susceptible primate species, such as macaques, can cause chronic wasting syndromes and a disease similar to the human acquired immunodeficiency syndrome (AIDS)⁵–¹⁰. Because of the similarities between the human and nonhuman lentiviruses, SIV and its susceptible primate host have become the principal model for studying the pathogenesis of AIDS and developing…

Original language	English (US)
Pages (from-to)	172-177
Number of pages	6
Journal	New England Journal of Medicine
Volume	330
Issue number	3
DOIs	https://doi.org/10.1056/NEJM199401203300304
State	Published - Jan 20 1994

ASJC Scopus subject areas

Medicine(all)

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Infection of a Laboratory Worker with Simian Immunodeficiency Virus. / Khabbaz, Rima F.; Heneine, Walid; George, J. Richard; Parekh, Bharat; Rowe, Thomas; Woods, Toni; Switzer, William M.; Mcclure, Harold M.; Murphey-Corb, Michael; Folks, Thomas M.

In: New England Journal of Medicine, Vol. 330, No. 3, 20.01.1994, p. 172-177.

Research output: Contribution to journal › Article › peer-review

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abstract = "Simian immunodeficiency viruses (SIVs) are primate lentiviruses that are morphologically similar and biologically related to human immunodeficiency viruses (HIVs)1–4. SIVs naturally infect some nonhuman primate species, such as African green monkeys and sooty mangabey monkeys, without causing immunodeficiency. In contrast, experimental SIV infection of other susceptible primate species, such as macaques, can cause chronic wasting syndromes and a disease similar to the human acquired immunodeficiency syndrome (AIDS)5–10. Because of the similarities between the human and nonhuman lentiviruses, SIV and its susceptible primate host have become the principal model for studying the pathogenesis of AIDS and developing…",

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