Infant diet affects serum lipoprotein concentrations and cholesterol esterifying enzymes in baboons

G. E. Mott, D. S. Lewis, C. A. McMahan

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We characterized the preweaning differences in cholesterol metabolism between breast-fed and formula-fed baboons and determined if formulas with low and high polyunsaturated:saturated fatty acid (P:S) ratios simulated the effects of breast feeding. At birth, 45 infant baboons from three sires and 44 dams were assigned to breast-fed, low P:S formula or high P:S formula diet groups until weaning at 14 wk. From 4 to 14 wk breast-fed infants had higher serum cholesterol because of much higher HDL1- and HDL2-cholesterol concentrations but had lower HDL3-cholesterol than both formula-fed groups. LDL-cholesterol was higher in infants fed the low P:S formula. Breast-fed infants had higher serum apolipoprotein E than the formula-fed groups, but diet did not affect apolipoprotein A-I or B concentrations. Breast-fed infants had higher hepatic acyl CoA cholesterol acyltransferase activity and lower plasma lecithin cholesterol acyltransferase activity. These enzyme activities were not different between infants fed low or high P:S formulas. Post-heparinized plasma lipoprotein lipase activity was greater in breast- fed infants than in those fed formula. These findings demonstrate that the P:S ratio of formulas has little effect on cholesterol metabolism during the preweaning period and suggest that factors other than fat composition account for the metabolic differences between breast feeding and commercial infant formula.

Original languageEnglish (US)
Pages (from-to)155-163
Number of pages9
JournalJournal of Nutrition
Volume123
Issue number2
StatePublished - 1993

Fingerprint

Sterol O-Acyltransferase
Papio
lipoproteins
Unsaturated Fatty Acids
cholesterol
Breast
Diet
Fatty Acids
breasts
saturated fatty acids
polyunsaturated fatty acids
feed formulation
enzymes
Serum
diet
Cholesterol
cholesterol metabolism
Breast Feeding
breast feeding
HDL Cholesterol

Keywords

  • baboons
  • breast feeding
  • cholesterol esterification
  • dietary fat
  • lipoproteins

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Infant diet affects serum lipoprotein concentrations and cholesterol esterifying enzymes in baboons. / Mott, G. E.; Lewis, D. S.; McMahan, C. A.

In: Journal of Nutrition, Vol. 123, No. 2, 1993, p. 155-163.

Research output: Contribution to journalArticle

Mott, G. E. ; Lewis, D. S. ; McMahan, C. A. / Infant diet affects serum lipoprotein concentrations and cholesterol esterifying enzymes in baboons. In: Journal of Nutrition. 1993 ; Vol. 123, No. 2. pp. 155-163.
@article{ffd85206f13e417bbb4525a9ecdce834,
title = "Infant diet affects serum lipoprotein concentrations and cholesterol esterifying enzymes in baboons",
abstract = "We characterized the preweaning differences in cholesterol metabolism between breast-fed and formula-fed baboons and determined if formulas with low and high polyunsaturated:saturated fatty acid (P:S) ratios simulated the effects of breast feeding. At birth, 45 infant baboons from three sires and 44 dams were assigned to breast-fed, low P:S formula or high P:S formula diet groups until weaning at 14 wk. From 4 to 14 wk breast-fed infants had higher serum cholesterol because of much higher HDL1- and HDL2-cholesterol concentrations but had lower HDL3-cholesterol than both formula-fed groups. LDL-cholesterol was higher in infants fed the low P:S formula. Breast-fed infants had higher serum apolipoprotein E than the formula-fed groups, but diet did not affect apolipoprotein A-I or B concentrations. Breast-fed infants had higher hepatic acyl CoA cholesterol acyltransferase activity and lower plasma lecithin cholesterol acyltransferase activity. These enzyme activities were not different between infants fed low or high P:S formulas. Post-heparinized plasma lipoprotein lipase activity was greater in breast- fed infants than in those fed formula. These findings demonstrate that the P:S ratio of formulas has little effect on cholesterol metabolism during the preweaning period and suggest that factors other than fat composition account for the metabolic differences between breast feeding and commercial infant formula.",
keywords = "baboons, breast feeding, cholesterol esterification, dietary fat, lipoproteins",
author = "Mott, {G. E.} and Lewis, {D. S.} and McMahan, {C. A.}",
year = "1993",
language = "English (US)",
volume = "123",
pages = "155--163",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "2",

}

TY - JOUR

T1 - Infant diet affects serum lipoprotein concentrations and cholesterol esterifying enzymes in baboons

AU - Mott, G. E.

AU - Lewis, D. S.

AU - McMahan, C. A.

PY - 1993

Y1 - 1993

N2 - We characterized the preweaning differences in cholesterol metabolism between breast-fed and formula-fed baboons and determined if formulas with low and high polyunsaturated:saturated fatty acid (P:S) ratios simulated the effects of breast feeding. At birth, 45 infant baboons from three sires and 44 dams were assigned to breast-fed, low P:S formula or high P:S formula diet groups until weaning at 14 wk. From 4 to 14 wk breast-fed infants had higher serum cholesterol because of much higher HDL1- and HDL2-cholesterol concentrations but had lower HDL3-cholesterol than both formula-fed groups. LDL-cholesterol was higher in infants fed the low P:S formula. Breast-fed infants had higher serum apolipoprotein E than the formula-fed groups, but diet did not affect apolipoprotein A-I or B concentrations. Breast-fed infants had higher hepatic acyl CoA cholesterol acyltransferase activity and lower plasma lecithin cholesterol acyltransferase activity. These enzyme activities were not different between infants fed low or high P:S formulas. Post-heparinized plasma lipoprotein lipase activity was greater in breast- fed infants than in those fed formula. These findings demonstrate that the P:S ratio of formulas has little effect on cholesterol metabolism during the preweaning period and suggest that factors other than fat composition account for the metabolic differences between breast feeding and commercial infant formula.

AB - We characterized the preweaning differences in cholesterol metabolism between breast-fed and formula-fed baboons and determined if formulas with low and high polyunsaturated:saturated fatty acid (P:S) ratios simulated the effects of breast feeding. At birth, 45 infant baboons from three sires and 44 dams were assigned to breast-fed, low P:S formula or high P:S formula diet groups until weaning at 14 wk. From 4 to 14 wk breast-fed infants had higher serum cholesterol because of much higher HDL1- and HDL2-cholesterol concentrations but had lower HDL3-cholesterol than both formula-fed groups. LDL-cholesterol was higher in infants fed the low P:S formula. Breast-fed infants had higher serum apolipoprotein E than the formula-fed groups, but diet did not affect apolipoprotein A-I or B concentrations. Breast-fed infants had higher hepatic acyl CoA cholesterol acyltransferase activity and lower plasma lecithin cholesterol acyltransferase activity. These enzyme activities were not different between infants fed low or high P:S formulas. Post-heparinized plasma lipoprotein lipase activity was greater in breast- fed infants than in those fed formula. These findings demonstrate that the P:S ratio of formulas has little effect on cholesterol metabolism during the preweaning period and suggest that factors other than fat composition account for the metabolic differences between breast feeding and commercial infant formula.

KW - baboons

KW - breast feeding

KW - cholesterol esterification

KW - dietary fat

KW - lipoproteins

UR - http://www.scopus.com/inward/record.url?scp=0027415555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027415555&partnerID=8YFLogxK

M3 - Article

C2 - 8429364

AN - SCOPUS:0027415555

VL - 123

SP - 155

EP - 163

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 2

ER -