Induction of telithromycin resistance by erythromycin in isolates of macrolide-resistant Staphylococcus spp.

Kepler A. Davis; Sharon A. Crawford; Kristin R. Fiebelkorn; James H. Jorgensen

doi:10.1128/AAC.49.7.3059-3061.2005

Induction of telithromycin resistance by erythromycin in isolates of macrolide-resistant Staphylococcus spp.

Kepler A. Davis, Sharon A. Crawford, Kristin R. Fiebelkorn, James H. Jorgensen

Department of Pathology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not discriminate between resistance due to an efflux mechanism (msrA) or a ribosomal target modification (ermA or ermC). Inducible telithromycin resistance in staphylococci does not appear to be analogous to inducible clindamycin resistance.

Original language	English (US)
Pages (from-to)	3059-3061
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	49
Issue number	7
DOIs	https://doi.org/10.1128/AAC.49.7.3059-3061.2005
State	Published - Jul 2005

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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10.1128/AAC.49.7.3059-3061.2005

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title = "Induction of telithromycin resistance by erythromycin in isolates of macrolide-resistant Staphylococcus spp.",

abstract = "Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not discriminate between resistance due to an efflux mechanism (msrA) or a ribosomal target modification (ermA or ermC). Inducible telithromycin resistance in staphylococci does not appear to be analogous to inducible clindamycin resistance.",

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AU - Davis, Kepler A.

AU - Crawford, Sharon A.

AU - Fiebelkorn, Kristin R.

AU - Jorgensen, James H.

PY - 2005/7

Y1 - 2005/7

N2 - Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not discriminate between resistance due to an efflux mechanism (msrA) or a ribosomal target modification (ermA or ermC). Inducible telithromycin resistance in staphylococci does not appear to be analogous to inducible clindamycin resistance.

AB - Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not discriminate between resistance due to an efflux mechanism (msrA) or a ribosomal target modification (ermA or ermC). Inducible telithromycin resistance in staphylococci does not appear to be analogous to inducible clindamycin resistance.

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Induction of telithromycin resistance by erythromycin in isolates of macrolide-resistant Staphylococcus spp.

Abstract

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