Induction of Suppressor Cell Activity by Human Pregnancy Serum

TSUNEYOSHI NAKAMURA, ROBERT H. PERSELLIN, I. JON RUSSELL

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

ABSTRACT: Third trimester pregnancy serum caused a dose‐dependent inhibition of the one‐way allogeneic mixed leukocyte reaction (MLR) through an effect that occurred during the first 48 hours of culture. Pregnancy serum also inhibited the mitogenic responsiveness of normal mononuclear leukocytes to concanavalin A (Con A) while the responses to phytohemagglutinin (PHA) and pokeweed mitogen (PWM) were less affected. Preincubation of normal peripheral blood mononuclear cells (PBMC) for 48 hours with 10% pregnancy serum enhanced a suppressor activity transferable with cells. These pregnancy serum‐induced effector cells suppressed the MLR only when they were autologous to the responder population (p < 0.05). The same suppressor cell preparation inhibited the proliferative responses of autologous PBMC to Con A (p < 0.001) and PWM (p < 0.05). These data suggest that one or more factors in pregnancy serum can induce or enhance suppressor cell activity in vitro. A comparable increase in suppressor cell activity in vivo may be responsible for blocking maternal rejection of the fetus and for the observed improvement in clinical activity of rheumatoid arthritis during pregnancy. 1983 Munksgaard

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalAmerican Journal of Reproductive Immunology
Volume4
Issue number3
DOIs
StatePublished - 1983

Keywords

  • mitogenic responses
  • mixed leukocyte reaction
  • Pregnancy serum
  • suppressor cell activity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

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