Induction of short-term biomarkers of tumor promotion in skin of CD-1 mice by petroleum middle distillates: preliminary observations.

C. Skisak, J. DiGiovanni, C. J. Conti, T. J. Slaga, S. Sharma, J. W. Sagartz, E. F. Walborg

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The induction of sustained epidermal hyperplasia in mouse skin has been shown to be a reliable predictor of tumor promoting activity for chemicals as diverse as phorbol esters, anthralins, n-dodecane and organic peroxides (DiGiovanni, 1992). The results contained herein demonstrate that API 81-07 and API 81-10, petroleum middle distillates that exhibit tumor promoting activity in mouse skin, induce epidermal hyperplasia and ODC activity. Other petroleum middle distillates (odorless light petroleum hydrocarbons, a light vacuum distillate, and a mineral seal oil) were also shown to share these activities. It should be emphasized that the relevance of these observations to human skin remains unresolved; however, the availability of these short-term biomarkers offers the opportunity to address the issue by performing comparative investigations on the effects of petroleum middle distillates on human skin xenografted to athymic (nude) mice. Such studies are being initiated.

Original languageEnglish (US)
Pages (from-to)439-444
Number of pages6
JournalProgress in clinical and biological research
Volume391
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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