Induction of lipid peroxidation in hamster organs by the carcinogen cadmium

Amelioration by melatonin

M. Karbownik, E. Gitto, A. Lewinski, Russel J Reiter

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Cadmium is a well-known human carcinogen. Lipid peroxidation is involved in cadmium-related toxicity and carcinogenesis. Melatonin is an effective antioxidant and free radical scavenger. The potential protective effects of melatonin against cadmium-induced lipid peroxidation in hamster brain, heart, kidney, testes, lung, and liver were examined. Lipid peroxidation was induced by intraperitoneal injection of cadmium chloride [single dose of 1 mg/kg body weight (bw)]. To test whether melatonin would protect against the toxicity of the carcinogen, the melatonin was injected peritoneally at a dose of either 15 mg/kg bw or 5 mg/kg bw, 0.5 h before cadmium treatment and thereafter at 8 h intervals during the day in the 48 h interval following the cadmium injection. One group of hamsters received only a single melatonin injection (a dose of 15 mg/kg bw, 30 min prior to cadmium). Forty-eight hours after cadmium injection, lipid peroxidation increased in brain, heart, kidney, testes, and lung. Either multiple injections of melatonin at both the 5 and 15 mg/kg bw doses, or a single injection of 15 mg/kg bw, prevented the cadmium-related increases in lipid peroxidation in brain, heart and lung. Cadmium-induced lipid peroxidation in kidney was prevented by melatonin when it was given as a single dose of 15 mg/kg bw. Melatonin slightly, but not significantly, reduced cadmium-induced lipid peroxidation in testes. It is concluded that cadmium toxicity, at least with regard to the resulting lipid peroxidation, is reduced by administering melatonin.

Original languageEnglish (US)
Pages (from-to)33-40
Number of pages8
JournalCell Biology and Toxicology
Volume17
Issue number1
DOIs
StatePublished - 2001

Fingerprint

Melatonin
Cadmium
Cricetinae
Carcinogens
Lipid Peroxidation
Lipids
Body Weight
Injections
Toxicity
Testis
Brain
Kidney
Lung
Cadmium Chloride
Free Radical Scavengers
Intraperitoneal Injections
Liver
Carcinogenesis
Antioxidants

Keywords

  • Cadmium
  • Carcinogen
  • Free radical
  • Lipid peroxidation
  • Melatonin

ASJC Scopus subject areas

  • Cell Biology
  • Toxicology

Cite this

Induction of lipid peroxidation in hamster organs by the carcinogen cadmium : Amelioration by melatonin. / Karbownik, M.; Gitto, E.; Lewinski, A.; Reiter, Russel J.

In: Cell Biology and Toxicology, Vol. 17, No. 1, 2001, p. 33-40.

Research output: Contribution to journalArticle

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