Induction of HTLV-III/LAV from a nonvirus-producing T-cell line: Implications for latency

Thomas Folks, Douglas M. Powell, Mailyn M. Lightfoote, Steven Benn, Macolm A. Martin, Anthony S. Fauci

    Research output: Contribution to journalArticlepeer-review

    200 Scopus citations

    Abstract

    When the human T-cell line A3.01 is infected with HTLV-III/LAV, the virus associated with the acquired immune deficiency syndrome (AIDS), most of the cells are killed. However, a small number of cells that lack the Leu-3 surface marker survive. Under normal conditions these surviving cells do not produce virus, nor can they be infected by the virus, but they can be induced to produce virus by treatment with 5-iodo-2′-deoxyuridine. This response can be induced for as long as 3 months after the initial infection, suggesting that the cells may harbor a latent form of HTLV-III/LAV.

    Original languageEnglish (US)
    Pages (from-to)600-602
    Number of pages3
    JournalScience
    Volume231
    Issue number4738
    DOIs
    StatePublished - Jan 1 1986

    ASJC Scopus subject areas

    • General

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