TY - JOUR
T1 - Induction of HTLV-III/LAV from a nonvirus-producing T-cell line
T2 - Implications for latency
AU - Folks, Thomas
AU - Powell, Douglas M.
AU - Lightfoote, Mailyn M.
AU - Benn, Steven
AU - Martin, Macolm A.
AU - Fauci, Anthony S.
PY - 1986/1/1
Y1 - 1986/1/1
N2 - When the human T-cell line A3.01 is infected with HTLV-III/LAV, the virus associated with the acquired immune deficiency syndrome (AIDS), most of the cells are killed. However, a small number of cells that lack the Leu-3 surface marker survive. Under normal conditions these surviving cells do not produce virus, nor can they be infected by the virus, but they can be induced to produce virus by treatment with 5-iodo-2′-deoxyuridine. This response can be induced for as long as 3 months after the initial infection, suggesting that the cells may harbor a latent form of HTLV-III/LAV.
AB - When the human T-cell line A3.01 is infected with HTLV-III/LAV, the virus associated with the acquired immune deficiency syndrome (AIDS), most of the cells are killed. However, a small number of cells that lack the Leu-3 surface marker survive. Under normal conditions these surviving cells do not produce virus, nor can they be infected by the virus, but they can be induced to produce virus by treatment with 5-iodo-2′-deoxyuridine. This response can be induced for as long as 3 months after the initial infection, suggesting that the cells may harbor a latent form of HTLV-III/LAV.
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U2 - 10.1126/science.3003906
DO - 10.1126/science.3003906
M3 - Article
C2 - 3003906
AN - SCOPUS:0022580049
VL - 231
SP - 600
EP - 602
JO - Science
JF - Science
SN - 0036-8075
IS - 4738
ER -