Induction of heat shock proteins in lymphocytes increases with mitogen stimulation

Mahmood Ghassemi, Ahmad R. Heydari, Arlan Richardson

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The effect of the growth state of a cell on the ability of hyperthermia to induce the synthesis of heat shock proteins (HSPs) was studied in resting and concanavalin A (ConA)-stimulated lymphocytes. Hyperthermia induced the synthesis of hsp 110, hsp 90, hsc 70, and hsp 70 in both resting and ConA-stimulated lymhocytes, and ConA-treatment induced the synthesis of the hsp 90 and hsc 70 at normal temperature. The induction of the synthesis of hsp 110 and hsp 70 by hyperthermia was 3- to 6-fold higher for lymphocytes cultured with ConA for 12 and 24 h than in non-stimulated lymphocytes. Thus, lymphocytes induced to undergo proliferation showed a greater response to hyperthermia than resting lymphocytes.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalImmunology Letters
Volume30
Issue number3
DOIs
StatePublished - Nov 1991

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Keywords

  • Heat shock
  • Heat shock protein
  • Hyperthermia
  • Lymphocyte

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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