Induction of bone resorbing activity by normal and rheumatoid arthritis T cells

Eliezer Flescher, Ian Ross Garrett, Gregory R. Mundy, Norman Talal

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We studied the role of T cells in the production of osteoclast activating factor (OAF) using anti-CD3 MAb as a specific T cell activator. OAF activity was totally inhibited by anti-IL-1β. Peripheral blood mononuclear cells (PBMNC) from normal subjects produced more OAF than did PBMNC from rheumatoid arthritis (RA) patients. Mononuclear cells (MNC) from RA synovial fluid produced less OAF than did RA peripheral blood. We conclude that (i) specific T cell stimulation induces OAF production which may be attributed to interleukin 1 (IL-1) activity, (ii) the inhibition by anti-IL-1β of OAF production following anti-CD3 stimulation suggests that the T cell signal is being transmitted to the macrophage, and (iii) RA MNC are deficient in T cell-mediated OAF production.

Original languageEnglish (US)
Pages (from-to)210-218
Number of pages9
JournalClinical Immunology and Immunopathology
Volume56
Issue number2
DOIs
StatePublished - Aug 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

Fingerprint

Dive into the research topics of 'Induction of bone resorbing activity by normal and rheumatoid arthritis T cells'. Together they form a unique fingerprint.

Cite this