Induction of an adaptive response in human blood lymphocytes exposed to radiofrequency fields: Influence of the universal mobile telecommunication system (UMTS) signal and the specific absorption rate

Olga Zeni, Anna Sannino, Stefania Romeo, Rita Massa, Maurizio Sarti, Abishek B. Reddy, Thomas J. Prihoda, Vijayalaxmi, Maria Rosaria Scarfì

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The induction of an adaptive response (AR) was examined in human peripheral blood lymphocytes exposed to non-ionizing radiofrequency fields (RF). Cells from nine healthy human volunteers were stimulated for 24. h with phytohaemagglutinin and then exposed for 20. h to an adaptive dose (AD) of a 1950. MHz RF UMTS (universal mobile telecommunication system) signal used for mobile communications, at different specific absorption rates (SAR) of 1.25, 0.6, 0.3, and 0.15. W/kg. This was followed by treatment of the cells at 48. h with a challenge dose (CD) of 100. ng/ml mitomycin C (MMC). Lymphocytes were collected at the end of the 72. h total culture period. The cytokinesis-block method was used to record the frequency of micronuclei (MN) as genotoxicity end-point. When lymphocytes from six donors were pre-exposed to RF at 0.3. W/kg SAR and then treated with MMC, these cells showed a significant reduction in the frequency of MN, compared with the cells treated with MMC alone; this result is indicative of induction of AR. The results from our earlier study indicated that lymphocytes that were stimulated for 24. h, exposed for 20. h to a 900. MHz RF GSM (global system for mobile communication) signal at 1.25. W/kg SAR and then treated with 100. ng/ml MMC, also exhibited AR. These overall data suggest that the induction of AR depends on RF frequency, type of the signal and SAR. Further characterization of RF-induced AR is in progress.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume747
Issue number1
DOIs
StatePublished - Aug 30 2012

Keywords

  • Adaptive response
  • Human blood lymphocytes
  • Micronuclei
  • Radiofrequency fields
  • Specific absorption rate
  • UMTS signal

ASJC Scopus subject areas

  • Genetics
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Induction of an adaptive response in human blood lymphocytes exposed to radiofrequency fields: Influence of the universal mobile telecommunication system (UMTS) signal and the specific absorption rate'. Together they form a unique fingerprint.

Cite this