Induction of adaptive response in human blood lymphocytes exposed to 900 MHz radiofrequency fields: Influence of cell cycle

Anna Sannino, Olga Zeni, Maurizio Sarti, Stefania Romeo, Siddharth B. Reddy, Maria Antonietta Belisario, Thomas J. Prihoda, Vijayalaxmi, Maria Rosaria Scarfi

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Purpose: To investigate the influence of cell cycle on the adaptive response (AR) induced by the exposure of human blood lymphocytes to radiofrequency fields (RF). Materials and methods: Human peripheral blood lymphocytes in G0-, G1- or S-phase of the cell cycle were exposed for 20 hours to an adaptive dose (AD) of 900 MHz RF at an average specific absorption rate of 1.25 W/kg and then treated with a challenge dose (CD) of 100 ng/ml mitomycin C (MMC). Un-exposed and sham-exposed controls as well as cells treated with MMC alone were included in the study. The incidence of micronuclei (MN) was evaluated to determine the induction of AR. Results: The results indicated that the cells which were exposed to AD of RF in G 0- and G1-phase of the cell cycle did not exhibit AR while such a response was observed when the cells were exposed to AD of RF in S-phase of the cell cycle. Conclusions: These results confirmed the observations reported in our previous investigation where AR was observed in human blood lymphocytes exposed to AD of RF in S-phase of the cell cycle and further suggested that the timing of AD exposure of RF is important to elicit AR.

Original languageEnglish (US)
Pages (from-to)993-999
Number of pages7
JournalInternational Journal of Radiation Biology
Volume87
Issue number9
DOIs
StatePublished - Sep 2011

Keywords

  • Adaptive response
  • Cell cycle
  • Human blood lymphocytes
  • Micronuclei
  • Radiofrequency fields

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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