Induction of adaptive response in human blood lymphocytes exposed to 900 MHz radiofrequency fields: Influence of cell cycle

Anna Sannino, Olga Zeni, Maurizio Sarti, Stefania Romeo, Siddharth B. Reddy, Maria Antonietta Belisario, Thomas J. Prihoda, Vijayalaxmi, Maria Rosaria Scarfi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Purpose: To investigate the influence of cell cycle on the adaptive response (AR) induced by the exposure of human blood lymphocytes to radiofrequency fields (RF). Materials and methods: Human peripheral blood lymphocytes in G0-, G1- or S-phase of the cell cycle were exposed for 20 hours to an adaptive dose (AD) of 900 MHz RF at an average specific absorption rate of 1.25 W/kg and then treated with a challenge dose (CD) of 100 ng/ml mitomycin C (MMC). Un-exposed and sham-exposed controls as well as cells treated with MMC alone were included in the study. The incidence of micronuclei (MN) was evaluated to determine the induction of AR. Results: The results indicated that the cells which were exposed to AD of RF in G 0- and G1-phase of the cell cycle did not exhibit AR while such a response was observed when the cells were exposed to AD of RF in S-phase of the cell cycle. Conclusions: These results confirmed the observations reported in our previous investigation where AR was observed in human blood lymphocytes exposed to AD of RF in S-phase of the cell cycle and further suggested that the timing of AD exposure of RF is important to elicit AR.

Original languageEnglish (US)
Pages (from-to)993-999
Number of pages7
JournalInternational Journal of Radiation Biology
Volume87
Issue number9
DOIs
StatePublished - Sep 2011
Externally publishedYes

Fingerprint

Cell Cycle
Lymphocytes
S Phase
Mitomycin
G1 Phase
Incidence

Keywords

  • Adaptive response
  • Cell cycle
  • Human blood lymphocytes
  • Micronuclei
  • Radiofrequency fields

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Induction of adaptive response in human blood lymphocytes exposed to 900 MHz radiofrequency fields : Influence of cell cycle. / Sannino, Anna; Zeni, Olga; Sarti, Maurizio; Romeo, Stefania; Reddy, Siddharth B.; Belisario, Maria Antonietta; Prihoda, Thomas J.; Vijayalaxmi; Scarfi, Maria Rosaria.

In: International Journal of Radiation Biology, Vol. 87, No. 9, 09.2011, p. 993-999.

Research output: Contribution to journalArticle

Sannino, A, Zeni, O, Sarti, M, Romeo, S, Reddy, SB, Belisario, MA, Prihoda, TJ, Vijayalaxmi & Scarfi, MR 2011, 'Induction of adaptive response in human blood lymphocytes exposed to 900 MHz radiofrequency fields: Influence of cell cycle', International Journal of Radiation Biology, vol. 87, no. 9, pp. 993-999. https://doi.org/10.3109/09553002.2011.574779
Sannino, Anna ; Zeni, Olga ; Sarti, Maurizio ; Romeo, Stefania ; Reddy, Siddharth B. ; Belisario, Maria Antonietta ; Prihoda, Thomas J. ; Vijayalaxmi ; Scarfi, Maria Rosaria. / Induction of adaptive response in human blood lymphocytes exposed to 900 MHz radiofrequency fields : Influence of cell cycle. In: International Journal of Radiation Biology. 2011 ; Vol. 87, No. 9. pp. 993-999.
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