TY - JOUR
T1 - Induction and Inhibition of Tumor Progression
AU - Warren, Barbour S.
AU - Naylor, Mark F.
AU - Winberg, Lloyd D.
AU - Yoshimi, Naoki
AU - Volpe, John P.G.
AU - Gimenez-Conti, Irma
AU - Slaga, Thomas J.
PY - 1993/1
Y1 - 1993/1
N2 - Carcinogenesis has been demonstrated by experimental and epidemiologic studies to be a multistage process composed of three major stages, initiation, promotion, and progression (1). The progression stage of this process encompasses the changes by which a tumor develops from a contained, differentiated lesion of uncoordinated growth into a rapidly growing, invasive lesion that can spread to other areas of the body, i.e., from a benign to a malignant tumor. Progression is of great therapeutic relevance because the process involves a change from a lesion that is easily treated surgically to one requiring extensive therapy with less favorable outcome.
AB - Carcinogenesis has been demonstrated by experimental and epidemiologic studies to be a multistage process composed of three major stages, initiation, promotion, and progression (1). The progression stage of this process encompasses the changes by which a tumor develops from a contained, differentiated lesion of uncoordinated growth into a rapidly growing, invasive lesion that can spread to other areas of the body, i.e., from a benign to a malignant tumor. Progression is of great therapeutic relevance because the process involves a change from a lesion that is easily treated surgically to one requiring extensive therapy with less favorable outcome.
UR - http://www.scopus.com/inward/record.url?scp=0027506021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027506021&partnerID=8YFLogxK
U2 - 10.3181/00379727-202-43511B
DO - 10.3181/00379727-202-43511B
M3 - Article
C2 - 8093814
AN - SCOPUS:0027506021
VL - 202
SP - 9
EP - 15
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
SN - 1535-3702
IS - 1
ER -