Induction and Inhibition of Tumor Progression

Barbour S. Warren, Mark F. Naylor, Lloyd D. Winberg, Naoki Yoshimi, John P.G. Volpe, Irma Gimenez-Conti, Thomas J. Slaga

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Carcinogenesis has been demonstrated by experimental and epidemiologic studies to be a multistage process composed of three major stages, initiation, promotion, and progression (1). The progression stage of this process encompasses the changes by which a tumor develops from a contained, differentiated lesion of uncoordinated growth into a rapidly growing, invasive lesion that can spread to other areas of the body, i.e., from a benign to a malignant tumor. Progression is of great therapeutic relevance because the process involves a change from a lesion that is easily treated surgically to one requiring extensive therapy with less favorable outcome.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
StatePublished - Jan 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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