Induced Pluripotent Stem Cells (iPSCs) Technology: Potential Targets for Depression

Gabriela D. Colpo, Antonio L. Teixeira

Research output: Chapter in Book/Report/Conference proceedingChapter


Major depressive disorder (MDD) is a heterogeneous condition with complex pathophysiology resulting from the interaction between genetic and environmental factors. Despite a reasonable array of therapeutic options, the management of MDD has been marked by an increasing number of treatment resistant cases. Identifying the multiple pathways involved in the pathogenesis of MDD is fundamental to move the field forward and to define novel and more effective therapeutic targets. The current disease models are not able to recapitulate the complexity of this condition. In the last years, induced pluripotent stem cells (iPSCs) have emerged as a unique tool to help the elucidation of the pathophysiology of psychiatric disorders through disease modeling. In addition, the iPSCs may play an important role in the validation of new therapeutic targets.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages9
StatePublished - 2021
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Cell therapy
  • Depression
  • Disease modeling
  • Drug screening
  • iPSCs

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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