Induced pluripotent stem cells from nonhuman primates

Anuja Mishra, Zhifang Qiu, Steven L. Farnsworth, Jacob J. Hemmi, Miao Li, Alexander V. Pickering, Peter J. Hornsby

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

Induced pluripotent stem cells from nonhuman primates (NHPs) have unique roles in cell biology and regenerative medicine. Because of the relatedness of NHPs to humans, NHP iPS cells can serve as a source of differentiated derivatives that can be used to address important questions in the comparative biology of primates. Additionally, when used as a source of cells for regenerative medicine, NHP iPS cells serve an invaluable role in translational experiments in cell therapy. Reprogramming of NHP somatic cells requires the same conditions as previously established for human cells. However, throughout the process, a variety of modifications to the human cell protocols must be made to accommodate significant species differences.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press
Pages183-193
Number of pages11
DOIs
StatePublished - Jan 1 2016

Publication series

NameMethods in Molecular Biology
Volume1357
ISSN (Print)1064-3745

Keywords

  • Induced pluripotent stem cells
  • Marmoset
  • Nonhuman primates
  • Reprogramming
  • Retroviruses
  • Teratoma

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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