Induced murine models of systemic lupus erythematosus

Yuan Xu, Leilani Zeumer, Westley H. Reeves, Laurence Morel

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Abstract

Induced mouse models of systemic lupus erythematosus (SLE) have been developed to complement the spontaneous models. This chapter describes the methods used in the pristane-induced model and the chronic graft-versus-host disease (cGVHD) model, both of which have been extensively used. We will also outline the specific mechanisms of systemic autoimmunity that can be best characterized using each of these models.

Original languageEnglish (US)
Title of host publicationSystemic Lupus Erythematosus
Subtitle of host publicationMethods and Protocols
PublisherHumana Press
Pages103-130
Number of pages28
ISBN (Print)9781493903252
DOIs
StatePublished - 2014
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1134
ISSN (Print)1064-3745

Keywords

  • Alveolar hemorrhage
  • Arthritis
  • Autoantibodies
  • Glomerulonephritis
  • Graft-versus-host disease
  • Mice
  • Murine lupus
  • Pristane
  • Sex difference
  • Systemic lupus erythematosus
  • Type 1 interferon

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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