Indomethacin enhancement of TPA tumor promotion in mice

S. M. Fischer, G. L. Gleason, G. D. Mills, Thomas J Slaga

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Skin tumor promotion in mice by 12-O-tetradecanoylphorbol-13-acetate (TPA) is characterized by hyperplasia and inflammation. Based on the inhibitory effect of the steroidal anti-inflammatory drugs, non-steroidal agents, such as indomethacin, were also expected to show some degree of inhibition; however, repeated tumor experiments demonstrate that indomethacin enhances TPA promotion in a dose-response manner. A time-of-application effect was evident such that indomethacin given 2 h prior to TPA resulted in the greatest enhancement. Flurbiprofen was also observed to enhance promotion slightly.

Original languageEnglish (US)
Pages (from-to)343-350
Number of pages8
JournalCancer Letters
Volume10
Issue number4
StatePublished - 1980
Externally publishedYes

Fingerprint

Tetradecanoylphorbol Acetate
Indomethacin
Flurbiprofen
Neoplasms
Non-Steroidal Anti-Inflammatory Agents
Hyperplasia
Inflammation
Skin
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Fischer, S. M., Gleason, G. L., Mills, G. D., & Slaga, T. J. (1980). Indomethacin enhancement of TPA tumor promotion in mice. Cancer Letters, 10(4), 343-350.

Indomethacin enhancement of TPA tumor promotion in mice. / Fischer, S. M.; Gleason, G. L.; Mills, G. D.; Slaga, Thomas J.

In: Cancer Letters, Vol. 10, No. 4, 1980, p. 343-350.

Research output: Contribution to journalArticle

Fischer, SM, Gleason, GL, Mills, GD & Slaga, TJ 1980, 'Indomethacin enhancement of TPA tumor promotion in mice', Cancer Letters, vol. 10, no. 4, pp. 343-350.
Fischer SM, Gleason GL, Mills GD, Slaga TJ. Indomethacin enhancement of TPA tumor promotion in mice. Cancer Letters. 1980;10(4):343-350.
Fischer, S. M. ; Gleason, G. L. ; Mills, G. D. ; Slaga, Thomas J. / Indomethacin enhancement of TPA tumor promotion in mice. In: Cancer Letters. 1980 ; Vol. 10, No. 4. pp. 343-350.
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