Indomethacin enhancement of TPA tumor promotion in mice

Susan M. Fischer, Greta L. Gleason, Gerald D. Mills, Thomas J. Slaga

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Skin tumor promotion in mice by 12-O-tetradecanoylphorbol-13-acetate (TPA) is characterized by hyperplasia and inflammation. Based on the inhibitory effect of the steroidal anti-inflammatory drugs, non-steroidal agents, such as indomethacin, were also expected to show some degree of inhibition; however, repeated tumor experiments demonstrate that indomethacin enhances TPA promotion in a dose-response manner. A time-of-application effect was evident such that indomethacin given 2 h prior to TPA resulted in the greatest enhancement. Flurbiprofen was also observed to enhance promotion slightly.

Original languageEnglish (US)
Pages (from-to)343-350
Number of pages8
JournalCancer Letters
Volume10
Issue number4
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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