TY - JOUR
T1 - Individual serum saturated fatty acids and markers of chronic subclinical inflammation
T2 - The Insulin Resistance Atherosclerosis Study
AU - Santaren, Ingrid D.
AU - Watkins, Steven M.
AU - Liese, Angela D.
AU - Wagenknecht, Lynne E.
AU - Rewers, Marian J.
AU - Haffner, Steven M.
AU - Lorenzo, Carlos
AU - Festa, Andreas
AU - Bazinet, Richard P.
AU - Hanley, Anthony J.
N1 - Funding Information:
This work was supported in part by the Dairy Research Cluster Initiative (Dairy Farmers of Canada, Agriculture and Agri-Food Canada, the Canadian Dairy Network, and the Canadian Dairy Commission). Additional funding was provided by the Ontario Graduate Scholarship; the University of Toronto’s Banting and Best Diabetes Centre, Novo Nordisk Graduate Studentship (I.D.S.). A.J.H. holds a Tier II Canada Research Chair in Diabetes Epidemiology. IRAS was supported by National Heart, Lung and Blood Institute grants U01-HL47887, U01-HL47889, U01-HL47892, U01-HL47902, DK-29867 and R01-58329 and the National Institutes of Health grant M01-RR-43. The contents of this work are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health. The authors declare no financial conflicts of interest relevant to this study. Manuscript received 11 April 2017 and in revised form 13 September 2017. Published, JLR Papers in Press, September 19, 2017 DOI https://doi.org/10.1194/jlr.P076836
Publisher Copyright:
Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc.
PY - 2017
Y1 - 2017
N2 - Recent evidence has documented distinct effects of individual saturated FAs (SFAs) on cardiometabolic outcomes, with potential protective effects from odd-and very long-chain SFAs (VLSFAs). Cross-sectional and prospective associations of individual serum SFAs (12:0, 14:0, 15:0, 16:0, 18:0, 20:0, 22:0, and total SFA) with proinflammatory biomarkers and adiponectin were investigated in 555 adults from the IRAS. Principal component analysis (PCA) of proinflammatory markers yielded three clusters: principal component (PC) 1: fibrinogen, white cell count, C-reactive protein; PC 2: plasminogen activator inhibitor-1 (PAI-1), TNF-α, IL-18; PC 3: IL-6 and IL-8. Cross-sectional analyses on proinflammatory PCs and adiponectin, and prospective analyses on 5 year PAI-1 and fibrinogen concentrations were conducted with multiple regression. Total SFA and 16:0 were positively associated with PC 1 and PC 2, and negatively associated with adiponectin. The 14:0 was positively associated with PC 1 and negatively associated with adiponectin. In contrast, 15:0, 20:0, and 22:0 were negatively associated with PC 2, and 20:0 and 22:0 were positively associated with adiponectin. The 18:0 was negatively associated with PC 3. Prospectively, 15:0, 18:0, 20:0, and 22:0 were negatively associated with 5 year PAI-1 concentrations. The results demonstrate that individual SFAs have distinct roles in subclinical in-flammation, highlighting the unique metabolic impacts of individual SFAs.
AB - Recent evidence has documented distinct effects of individual saturated FAs (SFAs) on cardiometabolic outcomes, with potential protective effects from odd-and very long-chain SFAs (VLSFAs). Cross-sectional and prospective associations of individual serum SFAs (12:0, 14:0, 15:0, 16:0, 18:0, 20:0, 22:0, and total SFA) with proinflammatory biomarkers and adiponectin were investigated in 555 adults from the IRAS. Principal component analysis (PCA) of proinflammatory markers yielded three clusters: principal component (PC) 1: fibrinogen, white cell count, C-reactive protein; PC 2: plasminogen activator inhibitor-1 (PAI-1), TNF-α, IL-18; PC 3: IL-6 and IL-8. Cross-sectional analyses on proinflammatory PCs and adiponectin, and prospective analyses on 5 year PAI-1 and fibrinogen concentrations were conducted with multiple regression. Total SFA and 16:0 were positively associated with PC 1 and PC 2, and negatively associated with adiponectin. The 14:0 was positively associated with PC 1 and negatively associated with adiponectin. In contrast, 15:0, 20:0, and 22:0 were negatively associated with PC 2, and 20:0 and 22:0 were positively associated with adiponectin. The 18:0 was negatively associated with PC 3. Prospectively, 15:0, 18:0, 20:0, and 22:0 were negatively associated with 5 year PAI-1 concentrations. The results demonstrate that individual SFAs have distinct roles in subclinical in-flammation, highlighting the unique metabolic impacts of individual SFAs.
KW - Cohort study
KW - Diet and dietary lipids
KW - Epidemiology
KW - Metabolic disease
UR - http://www.scopus.com/inward/record.url?scp=85033570083&partnerID=8YFLogxK
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U2 - 10.1194/jlr.P076836
DO - 10.1194/jlr.P076836
M3 - Article
C2 - 28928169
AN - SCOPUS:85033570083
SN - 0022-2275
VL - 58
SP - 2171
EP - 2179
JO - Journal of Lipid Research
JF - Journal of Lipid Research
IS - 11
ER -