Individual serum saturated fatty acids and markers of chronic subclinical inflammation: The Insulin Resistance Atherosclerosis Study

Ingrid D. Santaren, Steven M. Watkins, Angela D. Liese, Lynne E. Wagenknecht, Marian J. Rewers, Steven M. Haffner, Carlos Lorenzo, Andreas Festa, Richard P. Bazinet, Anthony J. Hanley

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Recent evidence has documented distinct effects of individual saturated FAs (SFAs) on cardiometabolic outcomes, with potential protective effects from odd-and very long-chain SFAs (VLSFAs). Cross-sectional and prospective associations of individual serum SFAs (12:0, 14:0, 15:0, 16:0, 18:0, 20:0, 22:0, and total SFA) with proinflammatory biomarkers and adiponectin were investigated in 555 adults from the IRAS. Principal component analysis (PCA) of proinflammatory markers yielded three clusters: principal component (PC) 1: fibrinogen, white cell count, C-reactive protein; PC 2: plasminogen activator inhibitor-1 (PAI-1), TNF-α, IL-18; PC 3: IL-6 and IL-8. Cross-sectional analyses on proinflammatory PCs and adiponectin, and prospective analyses on 5 year PAI-1 and fibrinogen concentrations were conducted with multiple regression. Total SFA and 16:0 were positively associated with PC 1 and PC 2, and negatively associated with adiponectin. The 14:0 was positively associated with PC 1 and negatively associated with adiponectin. In contrast, 15:0, 20:0, and 22:0 were negatively associated with PC 2, and 20:0 and 22:0 were positively associated with adiponectin. The 18:0 was negatively associated with PC 3. Prospectively, 15:0, 18:0, 20:0, and 22:0 were negatively associated with 5 year PAI-1 concentrations. The results demonstrate that individual SFAs have distinct roles in subclinical in-flammation, highlighting the unique metabolic impacts of individual SFAs.

Original languageEnglish (US)
Pages (from-to)2171-2179
Number of pages9
JournalJournal of lipid research
Volume58
Issue number11
DOIs
StatePublished - 2017

Keywords

  • Cohort study
  • Diet and dietary lipids
  • Epidemiology
  • Metabolic disease

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

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