Individual serum saturated fatty acids and markers of chronic subclinical inflammation

The Insulin Resistance Atherosclerosis Study

Ingrid D. Santaren, Steven M. Watkins, Angela D. Liese, Lynne E. Wagenknecht, Marian J. Rewers, Steven M. Haffner, Carlos Lorenzo, Andreas Festa, Richard P. Bazinet, Anthony J. Hanley

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Recent evidence has documented distinct effects of individual saturated FAs (SFAs) on cardiometabolic outcomes, with potential protective effects from odd-and very long-chain SFAs (VLSFAs). Cross-sectional and prospective associations of individual serum SFAs (12:0, 14:0, 15:0, 16:0, 18:0, 20:0, 22:0, and total SFA) with proinflammatory biomarkers and adiponectin were investigated in 555 adults from the IRAS. Principal component analysis (PCA) of proinflammatory markers yielded three clusters: principal component (PC) 1: fibrinogen, white cell count, C-reactive protein; PC 2: plasminogen activator inhibitor-1 (PAI-1), TNF-α, IL-18; PC 3: IL-6 and IL-8. Cross-sectional analyses on proinflammatory PCs and adiponectin, and prospective analyses on 5 year PAI-1 and fibrinogen concentrations were conducted with multiple regression. Total SFA and 16:0 were positively associated with PC 1 and PC 2, and negatively associated with adiponectin. The 14:0 was positively associated with PC 1 and negatively associated with adiponectin. In contrast, 15:0, 20:0, and 22:0 were negatively associated with PC 2, and 20:0 and 22:0 were positively associated with adiponectin. The 18:0 was negatively associated with PC 3. Prospectively, 15:0, 18:0, 20:0, and 22:0 were negatively associated with 5 year PAI-1 concentrations. The results demonstrate that individual SFAs have distinct roles in subclinical in-flammation, highlighting the unique metabolic impacts of individual SFAs.

Original languageEnglish (US)
Pages (from-to)2171-2179
Number of pages9
JournalJournal of Lipid Research
Volume58
Issue number11
DOIs
StatePublished - 2017

Fingerprint

Adiponectin
Insulin Resistance
Atherosclerosis
Fatty Acids
Insulin
Inflammation
Plasminogen Activator Inhibitor 1
Serum
Fibrinogen
Interleukin-18
Biomarkers
Principal Component Analysis
Interleukin-8
C-Reactive Protein
Principal component analysis
Interleukin-6
Cell Count
Cross-Sectional Studies

Keywords

  • Cohort study
  • Diet and dietary lipids
  • Epidemiology
  • Metabolic disease

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

Cite this

Santaren, I. D., Watkins, S. M., Liese, A. D., Wagenknecht, L. E., Rewers, M. J., Haffner, S. M., ... Hanley, A. J. (2017). Individual serum saturated fatty acids and markers of chronic subclinical inflammation: The Insulin Resistance Atherosclerosis Study. Journal of Lipid Research, 58(11), 2171-2179. https://doi.org/10.1194/jlr.P076836

Individual serum saturated fatty acids and markers of chronic subclinical inflammation : The Insulin Resistance Atherosclerosis Study. / Santaren, Ingrid D.; Watkins, Steven M.; Liese, Angela D.; Wagenknecht, Lynne E.; Rewers, Marian J.; Haffner, Steven M.; Lorenzo, Carlos; Festa, Andreas; Bazinet, Richard P.; Hanley, Anthony J.

In: Journal of Lipid Research, Vol. 58, No. 11, 2017, p. 2171-2179.

Research output: Contribution to journalArticle

Santaren, ID, Watkins, SM, Liese, AD, Wagenknecht, LE, Rewers, MJ, Haffner, SM, Lorenzo, C, Festa, A, Bazinet, RP & Hanley, AJ 2017, 'Individual serum saturated fatty acids and markers of chronic subclinical inflammation: The Insulin Resistance Atherosclerosis Study', Journal of Lipid Research, vol. 58, no. 11, pp. 2171-2179. https://doi.org/10.1194/jlr.P076836
Santaren, Ingrid D. ; Watkins, Steven M. ; Liese, Angela D. ; Wagenknecht, Lynne E. ; Rewers, Marian J. ; Haffner, Steven M. ; Lorenzo, Carlos ; Festa, Andreas ; Bazinet, Richard P. ; Hanley, Anthony J. / Individual serum saturated fatty acids and markers of chronic subclinical inflammation : The Insulin Resistance Atherosclerosis Study. In: Journal of Lipid Research. 2017 ; Vol. 58, No. 11. pp. 2171-2179.
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