Increases in SLT2 expression and chitin content are associated with incomplete killing of Candida glabrata by caspofungin

Jason M. Cota; Jodi L. Grabinski; Robert L. Talbert; David S. Burgess; P. David Rogers; Thomas D. Edlind; Nathan P. Wiederhold

doi:10.1128/AAC.01542-07

Increases in SLT2 expression and chitin content are associated with incomplete killing of Candida glabrata by caspofungin

Jason M. Cota, Jodi L. Grabinski, Robert L. Talbert, David S. Burgess, P. David Rogers, Thomas D. Edlind, Nathan P. Wiederhold

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Δslt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.

Original language	English (US)
Pages (from-to)	1144-1146
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	52
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01542-07
State	Published - Mar 2008

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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title = "Increases in SLT2 expression and chitin content are associated with incomplete killing of Candida glabrata by caspofungin",

abstract = "Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Δslt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.",

author = "Cota, {Jason M.} and Grabinski, {Jodi L.} and Talbert, {Robert L.} and Burgess, {David S.} and Rogers, {P. David} and Edlind, {Thomas D.} and Wiederhold, {Nathan P.}",

year = "2008",

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language = "English (US)",

volume = "52",

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AU - Cota, Jason M.

AU - Grabinski, Jodi L.

AU - Talbert, Robert L.

AU - Burgess, David S.

AU - Rogers, P. David

AU - Edlind, Thomas D.

AU - Wiederhold, Nathan P.

PY - 2008/3

Y1 - 2008/3

N2 - Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Δslt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.

AB - Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Δslt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.

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JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

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ER -

Increases in SLT2 expression and chitin content are associated with incomplete killing of Candida glabrata by caspofungin

Abstract

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