Increases in SLT2 expression and chitin content are associated with incomplete killing of Candida glabrata by caspofungin

Jason M. Cota, Jodi L. Grabinski, Robert L. Talbert, David S. Burgess, P. David Rogers, Thomas D. Edlind, Nathan P. Wiederhold

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Abstract

Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Δslt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.

Original languageEnglish (US)
Pages (from-to)1144-1146
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume52
Issue number3
DOIs
StatePublished - Mar 1 2008

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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