Increased Susceptibility to Infection Related to Extent of Burn Injury

Roger W. Yurt, Albert T. McManus, Arthur D. Mason, Basil A. Pruitt

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


• A model of burn wound sepsis in which the mortality caused by infection was significantly greater after a 60% total body surface area (TBSA) burn than after a 30% TBSA burn was developed in the rat. In rats that sustained a 60% TBSA burn (30% partial plus 30% full thickness), the 30% TBSA partial-thickness burn that was inoculated with Pseudomonas aeruginosa strain 59-1244 developed invasive wound infection (>105 colony-forming units per gram of tissue). Infection did not develop in rats that had a 30% TBSA partial-thickness burn inoculated, without additional injury. The additional burn in the rats with a 60% TBSA burn seemed to affect the development of infection in the partial-thickness wound and the overall outcome by a mechanism other than by infection of the full-thickness wound itself. Autopsy confirmed that mortality was caused by sepsis.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalArchives of Surgery
Issue number2
StatePublished - Feb 1984

ASJC Scopus subject areas

  • Surgery


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