TY - JOUR
T1 - Increased soluble TNF receptor 2 in antidepressant-free patients with late-life depression
AU - Diniz, Breno Satler
AU - Teixeira, Antonio Lucio
AU - Talib, Leda Leme
AU - Mendonça, Vanessa Amaral
AU - Gattaz, Wagner Farid
AU - Forlenza, Orestes Vicente
PY - 2010/10
Y1 - 2010/10
N2 - Increased pro-inflammatory state has been implicated in the pathophysiology of major depressive disorder. The aim of this study was to determine serum levels of TNF-α and soluble TNF-α receptors 1 and 2 (sTNFR1 and sTNFR2) in anti-depressant free depressed elderly patients as compared to healthy controls. Sixty-seven older adults (28 with major depression and 39 controls) were enrolled to this study. Participants were assessed by the SCID and diagnosis of major depressive episode was made according to the DSM-IV criteria. Serum TNF-α, sTNFR1 and sTNFR2 were determined by ELISA. Anti-depressant free patients with late-life depression showed an increased level of the sTNFR2 as compared to controls (p = 0.03). No significant differences were found in serum TNF-α and sTNFR1 levels (p = 0.1 and p = 0.4, respectively). There was no correlation between serum levels of these inflammatory markers and the severity of depression. Our findings provide additional evidence of the involvement of abnormal pro-inflammatory state in late-life depression.
AB - Increased pro-inflammatory state has been implicated in the pathophysiology of major depressive disorder. The aim of this study was to determine serum levels of TNF-α and soluble TNF-α receptors 1 and 2 (sTNFR1 and sTNFR2) in anti-depressant free depressed elderly patients as compared to healthy controls. Sixty-seven older adults (28 with major depression and 39 controls) were enrolled to this study. Participants were assessed by the SCID and diagnosis of major depressive episode was made according to the DSM-IV criteria. Serum TNF-α, sTNFR1 and sTNFR2 were determined by ELISA. Anti-depressant free patients with late-life depression showed an increased level of the sTNFR2 as compared to controls (p = 0.03). No significant differences were found in serum TNF-α and sTNFR1 levels (p = 0.1 and p = 0.4, respectively). There was no correlation between serum levels of these inflammatory markers and the severity of depression. Our findings provide additional evidence of the involvement of abnormal pro-inflammatory state in late-life depression.
KW - Early-onset depression
KW - Late-life depression
KW - Pathophysiology
KW - Tumor necrosis factor α
KW - Tumor necrosis factor α soluble receptor
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U2 - 10.1016/j.jpsychires.2010.02.008
DO - 10.1016/j.jpsychires.2010.02.008
M3 - Article
C2 - 20338581
AN - SCOPUS:77957667487
SN - 0022-3956
VL - 44
SP - 917
EP - 920
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 14
ER -