Increased soluble TNF receptor 2 in antidepressant-free patients with late-life depression

Breno Satler Diniz, Antonio Lucio Teixeira, Leda Leme Talib, Vanessa Amaral Mendonça, Wagner Farid Gattaz, Orestes Vicente Forlenza

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Increased pro-inflammatory state has been implicated in the pathophysiology of major depressive disorder. The aim of this study was to determine serum levels of TNF-α and soluble TNF-α receptors 1 and 2 (sTNFR1 and sTNFR2) in anti-depressant free depressed elderly patients as compared to healthy controls. Sixty-seven older adults (28 with major depression and 39 controls) were enrolled to this study. Participants were assessed by the SCID and diagnosis of major depressive episode was made according to the DSM-IV criteria. Serum TNF-α, sTNFR1 and sTNFR2 were determined by ELISA. Anti-depressant free patients with late-life depression showed an increased level of the sTNFR2 as compared to controls (p = 0.03). No significant differences were found in serum TNF-α and sTNFR1 levels (p = 0.1 and p = 0.4, respectively). There was no correlation between serum levels of these inflammatory markers and the severity of depression. Our findings provide additional evidence of the involvement of abnormal pro-inflammatory state in late-life depression.

Original languageEnglish (US)
Pages (from-to)917-920
Number of pages4
JournalJournal of Psychiatric Research
Issue number14
StatePublished - Oct 2010
Externally publishedYes


  • Early-onset depression
  • Late-life depression
  • Pathophysiology
  • Tumor necrosis factor α
  • Tumor necrosis factor α soluble receptor

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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