Increased serum levels of brain-derived neurotrophic factor in chronic institutionalized patients with schizophrenia

Helton José Reis, Rodrigo Nicolato, Izabela Guimarães Barbosa, Paulo Henrique Teixeira do Prado, Marco Aurélio Romano-Silva, Antonio Lucio Teixeira

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

There is a growing body of evidence implicating the neurotrophin brain-derived neurotrophic factor (BDNF) in the pathogenesis of schizophrenia. As circulating BDNF levels may reflect the BDNF levels in the brain, we assessed serum BDNF in 40 institutionalized schizophrenic patients and 20 healthy controls. Serum BNDF levels were significantly increased in schizophrenic patients when compared to control subjects (p < 0.001). Interestingly, serum BDNF correlated positively with the clinical scores at the negative subscale of the positive and negative syndrome scale (PANSS) (r = 0.41; p < 0.01). Our results confirm the emergent literature on the involvement of BDNF in schizophrenia.

Original languageEnglish (US)
Pages (from-to)157-159
Number of pages3
JournalNeuroscience Letters
Volume439
Issue number2
DOIs
StatePublished - Jul 11 2008
Externally publishedYes

Keywords

  • BDNF
  • Negative symptoms
  • Schizophrenia

ASJC Scopus subject areas

  • General Neuroscience

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