Increased serum levels of brain-derived neurotrophic factor in chronic institutionalized patients with schizophrenia

Helton José Reis; Rodrigo Nicolato; Izabela Guimarães Barbosa; Paulo Henrique Teixeira do Prado; Marco Aurélio Romano-Silva; Antonio Lucio Teixeira

doi:10.1016/j.neulet.2008.05.022

Increased serum levels of brain-derived neurotrophic factor in chronic institutionalized patients with schizophrenia

Helton José Reis, Rodrigo Nicolato, Izabela Guimarães Barbosa, Paulo Henrique Teixeira do Prado, Marco Aurélio Romano-Silva, Antonio Lucio Teixeira

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

There is a growing body of evidence implicating the neurotrophin brain-derived neurotrophic factor (BDNF) in the pathogenesis of schizophrenia. As circulating BDNF levels may reflect the BDNF levels in the brain, we assessed serum BDNF in 40 institutionalized schizophrenic patients and 20 healthy controls. Serum BNDF levels were significantly increased in schizophrenic patients when compared to control subjects (p < 0.001). Interestingly, serum BDNF correlated positively with the clinical scores at the negative subscale of the positive and negative syndrome scale (PANSS) (r = 0.41; p < 0.01). Our results confirm the emergent literature on the involvement of BDNF in schizophrenia.

Original language	English (US)
Pages (from-to)	157-159
Number of pages	3
Journal	Neuroscience Letters
Volume	439
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2008.05.022
State	Published - Jul 11 2008
Externally published	Yes

Keywords

BDNF
Negative symptoms
Schizophrenia

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2008.05.022

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title = "Increased serum levels of brain-derived neurotrophic factor in chronic institutionalized patients with schizophrenia",

abstract = "There is a growing body of evidence implicating the neurotrophin brain-derived neurotrophic factor (BDNF) in the pathogenesis of schizophrenia. As circulating BDNF levels may reflect the BDNF levels in the brain, we assessed serum BDNF in 40 institutionalized schizophrenic patients and 20 healthy controls. Serum BNDF levels were significantly increased in schizophrenic patients when compared to control subjects (p < 0.001). Interestingly, serum BDNF correlated positively with the clinical scores at the negative subscale of the positive and negative syndrome scale (PANSS) (r = 0.41; p < 0.01). Our results confirm the emergent literature on the involvement of BDNF in schizophrenia.",

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AU - Reis, Helton José

AU - Nicolato, Rodrigo

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AU - Romano-Silva, Marco Aurélio

AU - Teixeira, Antonio Lucio

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Increased serum levels of brain-derived neurotrophic factor in chronic institutionalized patients with schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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