Increased serum IL-1beta level in Alzheimer's disease and mild cognitive impairment.

Orestes Vicente Forlenza, Breno Satler Diniz, Leda Leme Talib, Vanessa Amaral Mendonça, Elida B. Ojopi, Wagner Farid Gattaz, Antonio Lucio Teixeira

Research output: Contribution to journalArticlepeer-review

171 Scopus citations

Abstract

Background/Aims: Abnormal inflammatory response has been associated to the pathogenesis of Alzheimer's disease (AD) and may be a marker of an ongoing neurodegenerative process. The aim of this study was to evaluate the serum levels of interleukin-1beta (IL-1beta) in patients with mild cognitive impairment (MCI) and AD. Methods: One hundred and sixty-three older adults (58 with mild to moderate AD, 74 with MCI and 31 healthy controls) were recruited for this study. Serum IL-1beta levels were measured by ELISA. Patients with MCI were subcategorized in single-domain amnestic (aMCI), nonamnestic (naMCI), and multiple-domain (mdMCI) subtypes. Results: Patients with AD and MCI (all subtypes) had a significant increase in serum IL-1beta levels as compared to controls (p = 0.03). Patients with mdMCI had serum IL-1beta levels comparable to those with AD, and significantly higher than those observed in aMCI and naMCI (p = 0.02). Discussion: The present study provides evidence that inflammatory mechanisms, represented by elevated IL-1beta, are observed in patients with MCI, specifically in those with impairment in multiple cognitive domains. As these patients are at higher risk of conversion to dementia, we propose that an increased serum IL-1beta level is a stage marker of the ongoing brain neurodegeneration in the continuum between normal ageing and AD.

Original languageEnglish (US)
Pages (from-to)507-512
Number of pages6
JournalDementia and Geriatric Cognitive Disorders
Volume28
Issue number6
DOIs
StatePublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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