Abstract
Sydenham's chorea (SC) is thought to result from the action of streptococcus-induced antibodies that cross react with basal ganglia antigens. Much less is known, however, about the involvement of cellular mechanisms in its pathogenesis. Since chemokines seem to play a role in several CNS inflammatory disorders, we sought to investigate the chemokine profile of patients with SC. Increased serum levels of CXCL9, formerly monokine induced by interferon-γ (Mig), and CXCL10, formerly interferon-γ-inducible protein of 10 kDa (IP-10) were demonstrated in acute SC patients, suggesting that a particular group of chemokines may be involved in SC pathogenesis.
Original language | English (US) |
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Pages (from-to) | 157-162 |
Number of pages | 6 |
Journal | Journal of Neuroimmunology |
Volume | 150 |
Issue number | 1-2 |
DOIs | |
State | Published - May 2004 |
Externally published | Yes |
Keywords
- Chemokines
- CXCL10
- CXCL9
- Cytokines
- Sydenham's chorea
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology