Increased serum concentrations of monokine induced by interferon-γ/ CXCL9 and interferon-γ-inducible protein 10/CXCL-10 in Sydenham's chorea patients

Antonio L. Teixeira, Francisco Cardoso, Adriano L.S. Souza, Mauro M. Teixeira

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Sydenham's chorea (SC) is thought to result from the action of streptococcus-induced antibodies that cross react with basal ganglia antigens. Much less is known, however, about the involvement of cellular mechanisms in its pathogenesis. Since chemokines seem to play a role in several CNS inflammatory disorders, we sought to investigate the chemokine profile of patients with SC. Increased serum levels of CXCL9, formerly monokine induced by interferon-γ (Mig), and CXCL10, formerly interferon-γ-inducible protein of 10 kDa (IP-10) were demonstrated in acute SC patients, suggesting that a particular group of chemokines may be involved in SC pathogenesis.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalJournal of Neuroimmunology
Volume150
Issue number1-2
DOIs
StatePublished - May 2004
Externally publishedYes

Keywords

  • Chemokines
  • CXCL10
  • CXCL9
  • Cytokines
  • Sydenham's chorea

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Increased serum concentrations of monokine induced by interferon-γ/ CXCL9 and interferon-γ-inducible protein 10/CXCL-10 in Sydenham's chorea patients'. Together they form a unique fingerprint.

Cite this