Increased production of TGF-beta and Il-6 by aged spleen cells

Daohong Zhou; F. Joseph Chrest; William Adler; Andrew Munster; Richard A. Winchurch

doi:10.1016/0165-2478(93)90061-6

Increased production of TGF-beta and Il-6 by aged spleen cells

Daohong Zhou
, F. Joseph Chrest
, William Adler
, Andrew Munster
, Richard A. Winchurch

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Aging is accompanied by a progressive decline in immunity in every species that has been studied. Despite its ubiquity, the causes of immunosenescence are unknown. Transforming growth factor beta (TGF-beta) is a cytokine with potent immunosuppressive properties. Cells from aged mice produce increased levels of TGF-beta in vitro along with similar increases in interleukin 6 (Il-6), a cytokine which is immunosuppressive at elevated concentrations. Il-6 does not upregulate TGF-beta production, but high concentrations of Il-6 increase the percentage of cells expressing the TGF-beta receptor. Increased TGF-beta production and Il-6-induced upregulation of the TGF-beta receptor may be factors contributing to age-associated immunosuppression.

Original language	English (US)
Pages (from-to)	7-11
Number of pages	5
Journal	Immunology Letters
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/0165-2478(93)90061-6
State	Published - Apr 1993
Externally published	Yes

Keywords

Cytokine
Immunity
Immunosenescence
Interleukin

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/0165-2478(93)90061-6

Cite this

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title = "Increased production of TGF-beta and Il-6 by aged spleen cells",

abstract = "Aging is accompanied by a progressive decline in immunity in every species that has been studied. Despite its ubiquity, the causes of immunosenescence are unknown. Transforming growth factor beta (TGF-beta) is a cytokine with potent immunosuppressive properties. Cells from aged mice produce increased levels of TGF-beta in vitro along with similar increases in interleukin 6 (Il-6), a cytokine which is immunosuppressive at elevated concentrations. Il-6 does not upregulate TGF-beta production, but high concentrations of Il-6 increase the percentage of cells expressing the TGF-beta receptor. Increased TGF-beta production and Il-6-induced upregulation of the TGF-beta receptor may be factors contributing to age-associated immunosuppression.",

keywords = "Cytokine, Immunity, Immunosenescence, Interleukin",

author = "Daohong Zhou and Chrest, \{F. Joseph\} and William Adler and Andrew Munster and Winchurch, \{Richard A.\}",

note = "Funding Information: Supported, in part, by a grant from the National Livestock and Meat Board.",

year = "1993",

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doi = "10.1016/0165-2478(93)90061-6",

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volume = "36",

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TY - JOUR

T1 - Increased production of TGF-beta and Il-6 by aged spleen cells

AU - Zhou, Daohong

AU - Chrest, F. Joseph

AU - Adler, William

AU - Munster, Andrew

AU - Winchurch, Richard A.

N1 - Funding Information: Supported, in part, by a grant from the National Livestock and Meat Board.

PY - 1993/4

Y1 - 1993/4

N2 - Aging is accompanied by a progressive decline in immunity in every species that has been studied. Despite its ubiquity, the causes of immunosenescence are unknown. Transforming growth factor beta (TGF-beta) is a cytokine with potent immunosuppressive properties. Cells from aged mice produce increased levels of TGF-beta in vitro along with similar increases in interleukin 6 (Il-6), a cytokine which is immunosuppressive at elevated concentrations. Il-6 does not upregulate TGF-beta production, but high concentrations of Il-6 increase the percentage of cells expressing the TGF-beta receptor. Increased TGF-beta production and Il-6-induced upregulation of the TGF-beta receptor may be factors contributing to age-associated immunosuppression.

AB - Aging is accompanied by a progressive decline in immunity in every species that has been studied. Despite its ubiquity, the causes of immunosenescence are unknown. Transforming growth factor beta (TGF-beta) is a cytokine with potent immunosuppressive properties. Cells from aged mice produce increased levels of TGF-beta in vitro along with similar increases in interleukin 6 (Il-6), a cytokine which is immunosuppressive at elevated concentrations. Il-6 does not upregulate TGF-beta production, but high concentrations of Il-6 increase the percentage of cells expressing the TGF-beta receptor. Increased TGF-beta production and Il-6-induced upregulation of the TGF-beta receptor may be factors contributing to age-associated immunosuppression.

KW - Cytokine

KW - Immunity

KW - Immunosenescence

KW - Interleukin

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UR - https://www.scopus.com/pages/publications/0027230586#tab=citedBy

U2 - 10.1016/0165-2478(93)90061-6

DO - 10.1016/0165-2478(93)90061-6

M3 - Article

C2 - 8393837

AN - SCOPUS:0027230586

SN - 0165-2478

VL - 36

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EP - 11

JO - Immunology Letters

JF - Immunology Letters

IS - 1

ER -

Increased production of TGF-beta and Il-6 by aged spleen cells

Abstract

Keywords

ASJC Scopus subject areas

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