Increased production of TGF-beta and Il-6 by aged spleen cells

Daohong Zhou, F. Joseph Chrest, William Adler, Andrew Munster, Richard A. Winchurch

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Aging is accompanied by a progressive decline in immunity in every species that has been studied. Despite its ubiquity, the causes of immunosenescence are unknown. Transforming growth factor beta (TGF-beta) is a cytokine with potent immunosuppressive properties. Cells from aged mice produce increased levels of TGF-beta in vitro along with similar increases in interleukin 6 (Il-6), a cytokine which is immunosuppressive at elevated concentrations. Il-6 does not upregulate TGF-beta production, but high concentrations of Il-6 increase the percentage of cells expressing the TGF-beta receptor. Increased TGF-beta production and Il-6-induced upregulation of the TGF-beta receptor may be factors contributing to age-associated immunosuppression.

Original languageEnglish (US)
Pages (from-to)7-11
Number of pages5
JournalImmunology Letters
Issue number1
StatePublished - Apr 1993
Externally publishedYes


  • Cytokine
  • Immunity
  • Immunosenescence
  • Interleukin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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