Increased Prevalence of Eosinophilic Esophagitis in Patients With Chronic Rhinosinusitis

Jordan K. Simmons, David A. Leiman, Sarita U. Patil, Edward McCoul, Philip G. Chen, Dennis M. Tang, Edward C. Kuan, Elena E. Chang, Arthur W. Wu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Chronic rhinosinusitis (CRS) and eosinophilic esophagitis (EoE) are immune-mediated inflammatory conditions that share common histopathologic features. Once considered two separate pathologies, preliminary data has suggested that a higher prevalence of EoE may exist in patients with CRS. Objectives: We aimed to expand the base of evidence across geographic regions and investigate the association between EoE and CRS, including CRS with nasal polyposis (CRSwNP). Methods: Quantitative data detailing the prevalence of CRS, CRSwNP, and EoE were pooled from 6 large academic institutions spread across the United States using Epic electronic medical record system. One-way analysis of variance was then used to analyze the data. Results: The mean prevalence of EoE in our general population sample of over 26 million individual records was 0.058% (range, 0.013%-0.103%). The mean prevalence of EoE in our sub-populations of individual with diagnoses of CRS and CRSwNP was 0.43% (F(1,12) = [8.194], P =.01) and 0.84% (F(1,12) = [23.61], P <.01) respectively. Conclusion: This study reveals an 8-fold greater prevalence of concurrent EoE in patients with CRS. Importantly, this is the first study to describe the association of EoE and the CRSwNP subtype, and we demonstrate a 14-fold greater prevalence of EoE in patients with CRSwNP.

Original languageEnglish (US)
Pages (from-to)804-807
Number of pages4
JournalAmerican Journal of Rhinology and Allergy
Volume36
Issue number6
DOIs
StatePublished - Nov 2022

Keywords

  • chronic rhinosinusitis
  • eosinophilic esophagitis
  • immune-mediated inflammation
  • nasal obstruction
  • nasal polyposis
  • post-nasal drip
  • rhinitis
  • rhinorrhea
  • sinusitis
  • Th2-mediated inflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology

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