Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse

Elizabeth Regina Comini Frota; David Henrique Rodrigues; Eduardo Antonio Donadi; Doralina G. Brum; Damacio Ramon Kaimen Maciel; Antônio Lúcio Teixeira

doi:10.1016/j.neulet.2009.05.057

Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse

Elizabeth Regina Comini Frota, David Henrique Rodrigues, Eduardo Antonio Donadi, Doralina G. Brum, Damacio Ramon Kaimen Maciel, Antônio Lúcio Teixeira

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Brain derived neurotrophic factor (BDNF) has been related to neuroprotection in a series of central nervous system diseases, although its role in multiple sclerosis (MS) was only partially investigated. In this work, we aimed to evaluate the plasma levels of BDNF from 29 MS patients and 24 control subjects. MS patients had decreased levels of BDNF in comparison with healthy controls. BDNF levels increased significantly after MS relapse. Our results provide some evidence for the involvement of BDNF in the pathogenesis of MS and suggest a role for this neurotrophin during the recovery of acute demyelinating inflammatory lesion.

Original language	English (US)
Pages (from-to)	130-132
Number of pages	3
Journal	Neuroscience Letters
Volume	460
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2009.05.057
State	Published - Aug 28 2009
Externally published	Yes

Keywords

Brain derived neurotrophic factor
Multiple sclerosis
Neuroprotection
Neurotrophins

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2009.05.057

Cite this

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title = "Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse",

abstract = "Brain derived neurotrophic factor (BDNF) has been related to neuroprotection in a series of central nervous system diseases, although its role in multiple sclerosis (MS) was only partially investigated. In this work, we aimed to evaluate the plasma levels of BDNF from 29 MS patients and 24 control subjects. MS patients had decreased levels of BDNF in comparison with healthy controls. BDNF levels increased significantly after MS relapse. Our results provide some evidence for the involvement of BDNF in the pathogenesis of MS and suggest a role for this neurotrophin during the recovery of acute demyelinating inflammatory lesion.",

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AU - Frota, Elizabeth Regina Comini

AU - Rodrigues, David Henrique

AU - Donadi, Eduardo Antonio

AU - Brum, Doralina G.

AU - Maciel, Damacio Ramon Kaimen

AU - Teixeira, Antônio Lúcio

PY - 2009/8/28

Y1 - 2009/8/28

N2 - Brain derived neurotrophic factor (BDNF) has been related to neuroprotection in a series of central nervous system diseases, although its role in multiple sclerosis (MS) was only partially investigated. In this work, we aimed to evaluate the plasma levels of BDNF from 29 MS patients and 24 control subjects. MS patients had decreased levels of BDNF in comparison with healthy controls. BDNF levels increased significantly after MS relapse. Our results provide some evidence for the involvement of BDNF in the pathogenesis of MS and suggest a role for this neurotrophin during the recovery of acute demyelinating inflammatory lesion.

AB - Brain derived neurotrophic factor (BDNF) has been related to neuroprotection in a series of central nervous system diseases, although its role in multiple sclerosis (MS) was only partially investigated. In this work, we aimed to evaluate the plasma levels of BDNF from 29 MS patients and 24 control subjects. MS patients had decreased levels of BDNF in comparison with healthy controls. BDNF levels increased significantly after MS relapse. Our results provide some evidence for the involvement of BDNF in the pathogenesis of MS and suggest a role for this neurotrophin during the recovery of acute demyelinating inflammatory lesion.

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Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse

Abstract

Keywords

ASJC Scopus subject areas

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