TY - JOUR
T1 - Increased plasma levels of BDNF and inflammatory markers in Alzheimer's disease
AU - Faria, Mayara Chaves
AU - Gonçalves, Gisele Santos
AU - Rocha, Natália Pessoa
AU - Moraes, Edgar Nunes
AU - Bicalho, Maria Aparecida
AU - Gualberto Cintra, Marco Túlio
AU - Jardim de Paula, Jonas
AU - José Ravic de Miranda, Luís Felipe
AU - Clayton de Souza Ferreira, Alessandro
AU - Teixeira, Ant Ônio Lúcio
AU - Gomes, Karina Braga
AU - Carvalho, Maria das Graças
AU - Sousa, Lirlândia P.
PY - 2014
Y1 - 2014
N2 - Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Neurotrophic factors and inflammatory markers may play considerable roles in AD. In this study we measured, through Enzyme-Linked Immunosorbent Assay, the plasma levels of brain derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF) and neuronal growth factor (NGF), as well as tumor necrosis factor-alpha soluble receptors, sTNFR1 and sTNFR2, and soluble intercellular adhesion molecule 1 (sICAM-1), in 50 AD patients, 37 patients with mild cognitive impairment (MCI) and 56 healthy elderly controls. BDNF levels, expressed as median and interquartile range, were higher for AD patients (2545.3, 1497.4-4153.4pg/ml) compared to controls (1503.8, 802.3-2378.4pg/ml), P<0.001. sICAM-1 was also higher in AD patients. sTNFR1 levels were increased in AD when compared to controls and also to MCI. GDNF, NGF and sTNFR2 levels showed no significant differences among the studied groups. The increase in BDNF might reflect a compensatory mechanism against early neurodegeneration and seems to be related to inflammation. sTNFR1 appears to mark not only the inflammatory state but also differentiates between MCI and AD, which may be an additional tool for differentiating degrees of cognitive impairment.
AB - Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Neurotrophic factors and inflammatory markers may play considerable roles in AD. In this study we measured, through Enzyme-Linked Immunosorbent Assay, the plasma levels of brain derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF) and neuronal growth factor (NGF), as well as tumor necrosis factor-alpha soluble receptors, sTNFR1 and sTNFR2, and soluble intercellular adhesion molecule 1 (sICAM-1), in 50 AD patients, 37 patients with mild cognitive impairment (MCI) and 56 healthy elderly controls. BDNF levels, expressed as median and interquartile range, were higher for AD patients (2545.3, 1497.4-4153.4pg/ml) compared to controls (1503.8, 802.3-2378.4pg/ml), P<0.001. sICAM-1 was also higher in AD patients. sTNFR1 levels were increased in AD when compared to controls and also to MCI. GDNF, NGF and sTNFR2 levels showed no significant differences among the studied groups. The increase in BDNF might reflect a compensatory mechanism against early neurodegeneration and seems to be related to inflammation. sTNFR1 appears to mark not only the inflammatory state but also differentiates between MCI and AD, which may be an additional tool for differentiating degrees of cognitive impairment.
KW - Biomarkers
KW - Brain derived neurotrophic factor
KW - Inflammation
KW - Neurodegeneration
KW - Neurotrophic factors
KW - Neurotrophins
KW - STNFR1
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UR - http://www.scopus.com/inward/citedby.url?scp=84897464653&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychires.2014.01.019
DO - 10.1016/j.jpsychires.2014.01.019
M3 - Article
C2 - 24576746
AN - SCOPUS:84897464653
SN - 0022-3956
VL - 53
SP - 166
EP - 172
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 1
ER -