Increased penicillin nonsusceptibility of nonvaccine- serotype invasive pneumococci other than serotypes 19A and 6A in Post-7-valent conjugate vaccine era

Robert E. Gertz, Zhongya Li, Fabiana C. Pimenta, Delois Jackson, Billie A. Juni, Ruth Lynfield, James H. Jorgensen, Maria Da Gloria Carvalho, Bernard W. Beall

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

According to population-based invasive pneumococcal surveillance in the United States during 2007, 898 (26%) of 3,511 isolates were penicillin nonsusceptible. Non-7-valent pneumococcal conjugate vaccine (PCV7) serotypes other than 19A accounted for 40% of these penicillin-nonsusceptible isolates; of these, serotypes 15A (11%), 23A (8%), 35B (8%), and 6C (5%) were most common (cumulatively 32% of penicillin-nonsusceptible isolates). Each except 6C represented a single serotype and clonal complex combination that predated the introduction of PCV7. We evaluated the genetic characteristics and nonsusceptibility to penicillin of non- PCV7 serotypes, and we found increased proportions of specific penicillin-nonsusceptible clones in serotypes 15A, 23A, 35B, and 6C, which potentially indicates a basic change of population structure within these individual serotypes.

Original languageEnglish (US)
Pages (from-to)770-775
Number of pages6
JournalJournal of Infectious Diseases
Volume201
Issue number5
DOIs
StatePublished - Mar 1 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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