TY - JOUR
T1 - Increased levels of adipokines in bipolar disorder
AU - Barbosa, Izabela Guimarães
AU - Rocha, Natalia Pessoa
AU - Miranda, Aline Silva de
AU - Magalhães, Pedro Vieira da Silva
AU - Huguet, Rodrigo Barreto
AU - Souza, Lirlandia Pires de
AU - Kapczinski, Flávio
AU - Teixeira, Antonio Lucio
PY - 2012/3
Y1 - 2012/3
N2 - Bipolar disorder (BD) is associated with considerable higher chronic medical comorbidities, overweight and obesity. Adipokines are adipocyte-derived secretory factors which have functions in immune response and seem to be associated with both BD and overweight. The aim of this study was to evaluate the plasma levels of adipokines (adiponectin, resistin and leptin) and TNF-α and its receptors (sTNFR1 and sTNFR2) in BD overweight patients in comparison with overweight controls. Thirty euthymic BD type-I patients and thirty controls matched by age, gender and body-mass index (BMI) were assessed by Mini-International Neuropsychiatric Interview, Young Mania and Hamilton Depression rating scales (YMRS and HDRS, respectively). Plasma levels of adiponectin, resistin, leptin, TNF-α and its soluble receptors were measured by ELISA. BD patients presented increased plasma levels of adiponectin (p < 0.001), leptin (p < 0.001) and sTNFR1 (p = 0.01). Plasma levels of adipokines were not correlated neither with clinical parameters nor TNF-α, sTNFR1 and sTNFR2 plasma levels. This study provides further support to the hypothesis of the immune/inflammatory imbalance in BD.
AB - Bipolar disorder (BD) is associated with considerable higher chronic medical comorbidities, overweight and obesity. Adipokines are adipocyte-derived secretory factors which have functions in immune response and seem to be associated with both BD and overweight. The aim of this study was to evaluate the plasma levels of adipokines (adiponectin, resistin and leptin) and TNF-α and its receptors (sTNFR1 and sTNFR2) in BD overweight patients in comparison with overweight controls. Thirty euthymic BD type-I patients and thirty controls matched by age, gender and body-mass index (BMI) were assessed by Mini-International Neuropsychiatric Interview, Young Mania and Hamilton Depression rating scales (YMRS and HDRS, respectively). Plasma levels of adiponectin, resistin, leptin, TNF-α and its soluble receptors were measured by ELISA. BD patients presented increased plasma levels of adiponectin (p < 0.001), leptin (p < 0.001) and sTNFR1 (p = 0.01). Plasma levels of adipokines were not correlated neither with clinical parameters nor TNF-α, sTNFR1 and sTNFR2 plasma levels. This study provides further support to the hypothesis of the immune/inflammatory imbalance in BD.
KW - Adipokines
KW - Biomarkers
KW - Bipolar disorder
KW - Inflammation
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=84857143050&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857143050&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychires.2011.11.010
DO - 10.1016/j.jpsychires.2011.11.010
M3 - Article
AN - SCOPUS:84857143050
SN - 0022-3956
VL - 46
SP - 389
EP - 393
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 3
ER -