Increased Intracranial Pressure in a Boy with Gorham-Stout Disease

Manisha K. Patel, Brent R. Mittelstaedt, Frank E. Valentin, Linda P. Thomas, Christian L. Carlson, Brian M. Faux, David T. Hsieh

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Gorham-Stout disease (GSD), also known as vanishing bone disease, is a rare disorder, which most commonly presents in children and young adults and is characterized by an excessive proliferation of lymphangiomatous tissue within the bones. This lymphangiomatous proliferation often affects the cranium and, due to the proximate location to the dura surrounding cerebrospinal fluid (CSF) spaces, can result in CSF leaks manifesting as intracranial hypotension with clinical symptoms to include orthostatic headache, nausea, and vertigo. We present the case of a boy with GSD and a known history of migraine headaches who presented with persistent headaches due to increased intracranial pressure. Although migraine had initially been suspected, he was eventually diagnosed with intracranial hypertension after developing ophthalmoplegia and papilledema. We describe the first known instance of successful medical treatment of increased intracranial pressure in a patient with GSD.

Original languageEnglish (US)
Pages (from-to)66-71
Number of pages6
JournalCase Reports in Neurology
Volume8
Issue number1
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • Gorham-Stout disease
  • Headache
  • Intracranial hypertension
  • Migraine

ASJC Scopus subject areas

  • Clinical Neurology

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  • Cite this

    Patel, M. K., Mittelstaedt, B. R., Valentin, F. E., Thomas, L. P., Carlson, C. L., Faux, B. M., & Hsieh, D. T. (2016). Increased Intracranial Pressure in a Boy with Gorham-Stout Disease. Case Reports in Neurology, 8(1), 66-71. https://doi.org/10.1159/000445318