Increased interictal serum levels of CXCL8/IL-8 and CCL3/MIP-1α in migraine

Halina Duarte, Antonio L. Teixeira, Natália P. Rocha, Renan B. Domingues

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Inflammatory mediators have been studied in migraine pathophysiology; however, their role is not yet well established. The aim of the present study was to investigate interictal chemokine levels and its association with clinical parameters and psychiatric comorbidities in migraine patients compared with controls. This was a cross-sectional study including age and gender matched migraine patients and controls. Beck Depression and Anxiety Inventories, Headache Impact Test, and Allodynia Symptom Checklist were recorded. Chemokines were measured by ELISA. Forty-nine migraine patients and forty-nine controls without headache were included. CXCL8/IL-8 and CCL3/MIP-1α levels were significantly higher among patients with migraine (P = 0.039 and 0.02, respectively) even after controlling for anxiety and depression scores. Chemokine levels were not correlated with migraine impact as well as allodynia scores. CXCL8/IL-8 and CCL3/MIP-1 α levels were raised in migraine, independently of psychiatric comorbidities, migraine impact, and allodynia.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalNeurological Sciences
Issue number2
StatePublished - Feb 2015
Externally publishedYes


  • Allodynia
  • Anxiety
  • Chemokines
  • Depression
  • Migraine

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health


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