Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/Nogo task

Ashley Acheson, Malle A. Tagamets, Laura M. Rowland, Charles W Mathias, Susan N. Wright, L. Elliot Hong, Peter Kochunov, Donald M Dougherty

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Youths with a family history of alcohol and other drug use disorders (FH+) are at a greater risk of developing substance use disorders than their peers with no such family histories (FH-), and this increased risk may be related to impaired maturation of forebrain circuitry. FH+ individuals have shown altered forebrain activity at rest and while performing cognitive tasks. However, it is not fully understood how forebrain activity is altered in FH+ individuals, and ultimately how these alterations may contribute to substance use disorder risk. Methods: In this study, we tested 72 FH+ and 32 FH- youths performing a go/no-go task and examined activations in blocks with only go trials (Go Only), blocks with 50% go and 50% no-go trials (Go/NoGo), and a contrast of those 2 blocks. Results: FH+ youths had significantly greater cerebral activations in both the Go and Go/NoGo blocks than FH- youths in regions including the posterior cingulate/precuneus, bilateral middle/superior temporal gyrus, and medial superior frontal gyrus with no significant group differences in the subtraction between Go Only and Go/NoGo blocks. Additionally, FH+ youths had moderately slower reaction times on go trials in the Go Only blocks. Conclusions: Our findings suggest that global activation increase in FH+ youths are modulated by FH density and are not specific to the inhibitory components of the task. This pattern of increased activations in FH+ youths may be at least partially due to impaired forebrain white matter development leading to greater activations/less efficient neural communication during task performance.

Original languageEnglish (US)
Pages (from-to)2944-2951
Number of pages8
JournalAlcoholism: Clinical and Experimental Research
Volume38
Issue number12
DOIs
StatePublished - Dec 1 2014

Fingerprint

Prosencephalon
Substance-Related Disorders
Chemical activation
Alcohols
Prefrontal Cortex
Parietal Lobe
Gyrus Cinguli
Task Performance and Analysis
Temporal Lobe
Reaction Time
Communication
Pharmaceutical Preparations

Keywords

  • Family History
  • Functional Magnetic Resonance Imaging
  • Go/No-Go
  • Risk
  • Substance Use

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/Nogo task. / Acheson, Ashley; Tagamets, Malle A.; Rowland, Laura M.; Mathias, Charles W; Wright, Susan N.; Hong, L. Elliot; Kochunov, Peter; Dougherty, Donald M.

In: Alcoholism: Clinical and Experimental Research, Vol. 38, No. 12, 01.12.2014, p. 2944-2951.

Research output: Contribution to journalArticle

Acheson, Ashley ; Tagamets, Malle A. ; Rowland, Laura M. ; Mathias, Charles W ; Wright, Susan N. ; Hong, L. Elliot ; Kochunov, Peter ; Dougherty, Donald M. / Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/Nogo task. In: Alcoholism: Clinical and Experimental Research. 2014 ; Vol. 38, No. 12. pp. 2944-2951.
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