Increased expression of TRIP13 drives the tumorigenesis of bladder cancer in association with the EGFR signaling pathway

Yanjun Gao, Shanhui Liu, Qi Guo, Su Zhang, Youli Zhao, Hanzhang Wang, Tianbao Li, Yuwen Gong, Yuhan Wang, Tao Zhang, Zhilong Dong, Dean Bacich, Wasim H. Chowdhury, Ronald Rodriguez, Zhiping Wang

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Thyroid hormone receptor interactor 13 (TRIP13) is a crucial regulator of the spindle apparatus checkpoint and double-stranded break repair. The abnormal expression of TRIP13 was recently found in several human cancers, whereas the role of TRIP13 in the development of bladder cancer (BCa) has not been fully elucidated. Here, we reported that TRIP13 expression was elevated in BCa tissues compared with normal bladder tissues. Notably, the increased expression of TRIP13 was correlated with advanced tumor stage, lymph node metastasis, distant metastasis and reduced survival in BCa patients. Knockdown of TRIP13 in bladder cancer cells suppressed proliferation, induced cell cycle arrest, promoted apoptosis, and impaired cell motility, ultimately inhibiting tumor xenograft growth. Mechanistic investigations revealed that TRIP13 directly bound to epidermal growth factor receptor (EGFR), modulating the EGFR signaling pathway. Furthermore, TRIP13 expression was positively correlated with EGFR expression in BCa specimens, and the high expression of both TRIP13 and EGFR predicted poor survival. Overall, our results underscore the crucial role of TRIP13 in the tumorigenesis of BCa and provide a novel biomarker and therapeutic target for BCa treatment.

Original languageEnglish (US)
Pages (from-to)1488-1499
Number of pages12
JournalInternational Journal of Biological Sciences
Volume15
Issue number7
DOIs
StatePublished - 2019

Keywords

  • Bladder cancer
  • EGFR
  • TRIP13
  • Tumorigenesis

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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