TY - JOUR
T1 - Increased carotid intima-media thickness in the physiologic range is associated with impaired postprandial glucose metabolism, insulin resistance and beta cell dysfunction
AU - Andreozzi, F.
AU - Gastaldelli, A.
AU - Mannino, G. C.
AU - Sciacqua, A.
AU - Succurro, E.
AU - Arturi, F.
AU - Folli, F.
AU - Perticone, F.
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Background: Carotid Intima-Media Thickness (C-IMT) is a reliable predictor of cardiovascular events. We examined if increased C-IMT was associated with defects in glucose metabolism in non-diabetic subjects independently of age. Methods: In 366 Caucasian non-diabetic subjects of the CARAMERIS study, we measured glucose response during a 75g-Oral Glucose Tolerance Test (OGTT), insulin sensitivity index (ISI, by Matsuda Index), Liver Insulin Resistance Index (Liver-IR), insulin secretion by δAUC Ins0-120/Glu0-120 (δI/δG) and beta cell function (Disposition Index, DI). Results: Subjects were divided in two groups according to the median age (AGE1≤45y; AGE2>45y). Only 5 subjects in AGE1 and 32 in AGE2 had C-IMT>0.9mm. Compared to AGE1, AGE2 had a worse cardio-metabolic profile, increased cholesterol, glucose and insulin concentrations, blood pressure and C-IMT. Both δI/δG ratio and DI were significantly reduced in AGE2. By considering tertiles of C-IMT in each AGE group (G1-G3, where G3 comprised the highest C-IMT), we found that G3 showed increased OGTT glucose profiles and Liver IR, decreased ISI and DI, compared to G1 in each AGE group. Conclusions: Increased C-IMT, but within normal ranges, is associated independently of age with altered postprandial glucose profile, increased peripheral and hepatic insulin resistance, decreased b-cell function. C-IMT measurement should become a routine analysis even in younger subjects to predict the risk of cardio-metabolic disease.
AB - Background: Carotid Intima-Media Thickness (C-IMT) is a reliable predictor of cardiovascular events. We examined if increased C-IMT was associated with defects in glucose metabolism in non-diabetic subjects independently of age. Methods: In 366 Caucasian non-diabetic subjects of the CARAMERIS study, we measured glucose response during a 75g-Oral Glucose Tolerance Test (OGTT), insulin sensitivity index (ISI, by Matsuda Index), Liver Insulin Resistance Index (Liver-IR), insulin secretion by δAUC Ins0-120/Glu0-120 (δI/δG) and beta cell function (Disposition Index, DI). Results: Subjects were divided in two groups according to the median age (AGE1≤45y; AGE2>45y). Only 5 subjects in AGE1 and 32 in AGE2 had C-IMT>0.9mm. Compared to AGE1, AGE2 had a worse cardio-metabolic profile, increased cholesterol, glucose and insulin concentrations, blood pressure and C-IMT. Both δI/δG ratio and DI were significantly reduced in AGE2. By considering tertiles of C-IMT in each AGE group (G1-G3, where G3 comprised the highest C-IMT), we found that G3 showed increased OGTT glucose profiles and Liver IR, decreased ISI and DI, compared to G1 in each AGE group. Conclusions: Increased C-IMT, but within normal ranges, is associated independently of age with altered postprandial glucose profile, increased peripheral and hepatic insulin resistance, decreased b-cell function. C-IMT measurement should become a routine analysis even in younger subjects to predict the risk of cardio-metabolic disease.
KW - Atherosclerosis
KW - C-IMT
KW - OGTT
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U2 - 10.1016/j.atherosclerosis.2013.05.028
DO - 10.1016/j.atherosclerosis.2013.05.028
M3 - Article
C2 - 23880176
AN - SCOPUS:84880399106
VL - 229
SP - 277
EP - 281
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 2
ER -