Increased carotid intima-media thickness in the physiologic range is associated with impaired postprandial glucose metabolism, insulin resistance and beta cell dysfunction

F. Andreozzi, A. Gastaldelli, G. C. Mannino, A. Sciacqua, E. Succurro, F. Arturi, F. Folli, F. Perticone

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: Carotid Intima-Media Thickness (C-IMT) is a reliable predictor of cardiovascular events. We examined if increased C-IMT was associated with defects in glucose metabolism in non-diabetic subjects independently of age. Methods: In 366 Caucasian non-diabetic subjects of the CARAMERIS study, we measured glucose response during a 75g-Oral Glucose Tolerance Test (OGTT), insulin sensitivity index (ISI, by Matsuda Index), Liver Insulin Resistance Index (Liver-IR), insulin secretion by δAUC Ins0-120/Glu0-120 (δI/δG) and beta cell function (Disposition Index, DI). Results: Subjects were divided in two groups according to the median age (AGE1≤45y; AGE2>45y). Only 5 subjects in AGE1 and 32 in AGE2 had C-IMT>0.9mm. Compared to AGE1, AGE2 had a worse cardio-metabolic profile, increased cholesterol, glucose and insulin concentrations, blood pressure and C-IMT. Both δI/δG ratio and DI were significantly reduced in AGE2. By considering tertiles of C-IMT in each AGE group (G1-G3, where G3 comprised the highest C-IMT), we found that G3 showed increased OGTT glucose profiles and Liver IR, decreased ISI and DI, compared to G1 in each AGE group. Conclusions: Increased C-IMT, but within normal ranges, is associated independently of age with altered postprandial glucose profile, increased peripheral and hepatic insulin resistance, decreased b-cell function. C-IMT measurement should become a routine analysis even in younger subjects to predict the risk of cardio-metabolic disease.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalAtherosclerosis
Volume229
Issue number2
DOIs
Publication statusPublished - Aug 1 2013

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Keywords

  • Atherosclerosis
  • C-IMT
  • OGTT

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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